Geminin 抗体 (AA 71-202)
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北京 101111
Quick Overview for Geminin 抗体 (AA 71-202) (ABIN7876601)
抗原
See all Geminin (GMNN) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 71-202
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原理
- GMNN Antibody / Geminin
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纯化方法
- Protein A/G affinity
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免疫原
- A portion of amino acids 71-202 was used as the immunogen for the GMNN antibody.
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亚型
- IgG1, kappa
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anti-Geminin, DNA Replication Inhibitor (GMNN) (AA 110-209) antibody
GMNN 适用: 人 WB, IF, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1A8 unconjugated
anti-Geminin, DNA Replication Inhibitor (GMNN) (AA 1-206) antibodyGMNN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Geminin, DNA Replication Inhibitor (GMNN) antibodyGMNN 适用: 人 IHC, IF 宿主: 小鼠 Monoclonal CPTC-GMNN-1 unconjugated
anti-Geminin, DNA Replication Inhibitor (GMNN) (AA 110-142) antibodyGMNN 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Geminin, DNA Replication Inhibitor (GMNN) (AA 110-209) antibodyGMNN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B10 unconjugated
anti-Geminin, DNA Replication Inhibitor (GMNN) (AA 1-209) antibodyGMNN 适用: 人 IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Geminin, DNA Replication Inhibitor (GMNN) antibodyKD Validated GMNN 适用: 人 WB 宿主: 兔 Monoclonal 25GB3475 unconjugated Recombinant Antibody
anti-Geminin, DNA Replication Inhibitor (GMNN) (AA 96-123) antibodyGMNN 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB20074 unconjugated
anti-Geminin, DNA Replication Inhibitor (GMNN) (AA 21-196) antibodyGMNN 适用: 人, 小鼠 WB, IHC, IF, ELISA, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Geminin, DNA Replication Inhibitor (GMNN) (AA 1-209) antibodyGMNN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GMNN antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the GMNN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))
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别名
- GMNN
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背景
- Geminin is a nuclear protein that regulates the initiation of DNA replication during the cell cycle. DNA replication requires the coordinated association of Cdc6 and minichromosome maintenance (MCM) proteins with chromatin. Geminin blocks this assembly of the MCM into the prereplication complex and, in turn, prevents replication from occurring. Expression of Geminin fluctuates throughout the cell cycle with Geminin levels lowest at G1. Throughout S, G2 and M phases, Geminin levels are consistently elevated followed by a decrease during mitosis. The initiation of DNA replication is dependent on the degradation of Geminin during mitosis and the absence of Geminin throughout G1 phase. Geminin degradation is mediated by the anaphase-promoting complex (APC), which specifically targets B-type cyclins and other proteins containing a destruction box motif for degradation by ubiquitin-mediated proteolysis. While geminin expression is essential in maintaining chromosomal integrity, it is frequently overexpressed in cancers and evidence suggests that it plays a significant role in tumor proliferation and progression.
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UniProt
- O75496
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途径
- EGFR Signaling Pathway, DNA Replication
抗原
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