STXBP3 抗体 (AA 7-592)
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Quick Overview for STXBP3 抗体 (AA 7-592) (ABIN7876509)
抗原
See all STXBP3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 7-592
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原理
- STXBP3 Antibody / Syntaxin binding protein 3
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human STXBP3 recombinant protein (Position: E7-E592) was used as the immunogen for the STXBP3 antibody.
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亚型
- IgG
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anti-Syntaxin Binding Protein 3 (STXBP3) (AA 266-528) antibody
STXBP3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin Binding Protein 3 (STXBP3) (AA 343-592) antibodySTXBP3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin Binding Protein 3 (STXBP3) (AA 145-171) antibodySTXBP3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB17357 unconjugated
anti-Syntaxin Binding Protein 3 (STXBP3) (AA 1-592) antibodySTXBP3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Syntaxin Binding Protein 3 (STXBP3) (AA 1-225) antibodySTXBP3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G12 unconjugated
anti-Syntaxin Binding Protein 3 (STXBP3) (Internal Region) antibodyVerified STXBP3 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Syntaxin Binding Protein 3 (STXBP3) (C-Term) antibodySTXBP3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin Binding Protein 3 (STXBP3) (AA 144-171), (Middle Region) antibodySTXBP3 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the STXBP3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the STXBP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- STXBP3 (Syntaxin Binding Protein 3 (STXBP3))
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别名
- STXBP3
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背景
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STXBP3 antibody recognizes Syntaxin binding protein 3, a member of the Sec1/Munc18-like (SM) family of proteins that regulate vesicle fusion and exocytosis. The STXBP3 gene encodes a cytosolic protein also known as Munc18c, which interacts with syntaxins, particularly Syntaxin 4, to mediate docking and fusion of vesicles with the plasma membrane. This interaction is critical for regulated exocytosis in diverse cell types including adipocytes, pancreatic beta cells, neurons, and epithelial cells. By controlling SNARE complex assembly, STXBP3 ensures proper timing of vesicle release during insulin secretion, neurotransmission, and cell-surface trafficking of key receptors and transporters.
STXBP3 plays a central role in glucose homeostasis. In adipose and muscle tissue, Munc18c regulates insulin-stimulated translocation of glucose transporter 4 (GLUT4) to the plasma membrane, an essential step in glucose uptake. Dysregulation or reduced expression of STXBP3 has been associated with insulin resistance and type 2 diabetes. In pancreatic beta cells, STXBP3 interacts with Syntaxin 1A and VAMP2 to influence insulin granule exocytosis. Beyond metabolic regulation, STXBP3 participates in vesicle trafficking in epithelial tissues and contributes to cell polarity maintenance and junctional organization.
The human STXBP3 gene is located on chromosome 1p36.23 and contains multiple alternatively spliced isoforms. Protein structure analysis reveals that STXBP3 comprises three domains that form a closed conformation around its syntaxin partners, preventing premature SNARE complex formation. This inhibitory mechanism ensures vesicles only fuse in response to proper signaling cues. The protein's expression is ubiquitous but enriched in secretory tissues and endocrine glands. STXBP3 has also been implicated in immune responses through regulation of vesicle-mediated cytokine release.
Immunohistochemical staining with STXBP3 antibody demonstrates cytoplasmic localization in skeletal muscle, pancreatic islets, and epithelial cells. It serves as a valuable reagent for studies of insulin signaling, exocytosis, vesicular transport, and metabolic regulation. The STXBP3 antibody from NSJ Bioreagents provides a versatile tool for examining vesicle fusion mechanisms and SNARE complex dynamics across various cellular systems. -
UniProt
- O00186
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途径
- Hormone Transport
抗原
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