RASL12 抗体 (AA 7-261)
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北京 101111
Quick Overview for RASL12 抗体 (AA 7-261) (ABIN7876474)
抗原
See all RASL12 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 7-261
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原理
- RASL12 Antibody / Ras-like protein family member 12
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human RASL12 recombinant protein (Position: K7-K261) was used as the immunogen for the RASL12 antibody.
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亚型
- IgG
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anti-RAS-Like, Family 12 (RASL12) (AA 1-266) antibody
RASL12 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-RAS-Like, Family 12 (RASL12) (N-Term) antibodyRASL12 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-RAS-Like, Family 12 (RASL12) (N-Term) antibodyRASL12 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, Pig, Hamster, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-RAS-Like, Family 12 (RASL12) (AA 229-255), (C-Term) antibodyRASL12 适用: 人 WB 宿主: 兔 Polyclonal RB38344 unconjugated
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应用备注
- Optimal dilution of the RASL12 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the RASL12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- RASL12 (RAS-Like, Family 12 (RASL12))
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别名
- RASL12
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背景
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RASL12 antibody detects Ras-like protein family member 12, encoded by the RASL12 gene. Ras-like protein family member 12 is a small GTP binding protein that belongs to the Ras superfamily, which regulates signal transduction, cell growth, and cytoskeletal organization. RASL12 antibody provides researchers with a specific reagent for studying small GTPases and their influence on cellular signaling and differentiation.
Ras-like protein family member 12 is less well characterized than classical Ras proteins, but research using RASL12 antibody has shown that it retains the conserved GTP binding and hydrolysis domains characteristic of the Ras family. Through these domains, it likely regulates intracellular signaling cascades linked to growth, adhesion, and movement. Expression studies have shown that RASL12 is present in multiple tissues, suggesting broad cellular roles.
Studies with RASL12 antibody have revealed that Ras-like protein family member 12 may regulate cell cycle progression and survival pathways. Its sequence homology to other Ras proteins suggests involvement in MAPK and PI3K signaling networks, although specific effectors remain under investigation. Understanding the role of RASL12 may uncover new mechanisms of Ras family signaling and its impact on development and disease.
Dysregulation of RASL12 has been linked to tumor biology. Research using RASL12 antibody has demonstrated altered expression patterns in certain cancers, where imbalance may contribute to abnormal proliferation and survival. These findings support further investigation into its potential as a cancer biomarker and therapeutic target.
RASL12 antibody is commonly applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects endogenous expression in tissues and cell lines, immunohistochemistry reveals tissue-specific localization, and immunofluorescence highlights subcellular distribution. These approaches make RASL12 antibody valuable for research into Ras signaling networks.
By providing validated RASL12 antibody reagents, NSJ Bioreagents supports studies into Ras superfamily proteins, signal transduction, and cancer. Detection of Ras-like protein family member 12 offers researchers insight into how small GTPases integrate cellular signaling. -
UniProt
- Q9NYN1
抗原
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