DLAT 抗体 (AA 69-642)
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北京 101111
Quick Overview for DLAT 抗体 (AA 69-642) (ABIN7876449)
抗原
See all DLAT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 69-642
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原理
- DLAT Antibody / Pyruvate Dehydrogenase E2
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纯化方法
- Affinity purified
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免疫原
- An E. coli-derived human protein (amino acids P69-P642) was used as the immunogen for the DLAT antibody.
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亚型
- IgG
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anti-Dihydrolipoyl Transacetylase (DLAT) (AA 368-626) antibody
DLAT 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) antibodyKD Validated DLAT 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB805 unconjugated Recombinant Antibody
anti-Dihydrolipoyl Transacetylase (DLAT) antibodyDLAT 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) (AA 87-270) antibodyDLAT 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) (AA 1-647) antibodyDLAT 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) (AA 1-647) antibodyDLAT 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) (AA 579-607), (C-Term) antibodyDLAT 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB26843 unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) (N-Term) antibodyDLAT 适用: 人, 小鼠, 大鼠, 兔, 犬, 斑马鱼, Cow, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) antibodyDLAT 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Dihydrolipoyl Transacetylase (DLAT) antibodyDLAT 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the DLAT antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the DLAT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- DLAT (Dihydrolipoyl Transacetylase (DLAT))
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别名
- DLAT
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背景
- Dihydrolipoyl transacetylase (or dihydrolipoamide acetyltransferase) is an enzyme component of the multienzyme pyruvate dehydrogenase complex. This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95 % of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.
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UniProt
- P10515
抗原
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