RPE 抗体 (AA 68-110)
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Quick Overview for RPE 抗体 (AA 68-110) (ABIN7876396)
抗原
See all RPE 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 68-110
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原理
- RPE Antibody / Ribulose-phosphate 3-epimerase
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纯化方法
- Antigen affinity chromatography
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免疫原
- An E.coli-derived human recombinant protein (amino acids D68-E110) was used as the immunogen for the RPE antibody.
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亚型
- IgG
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anti-Ribulose-5-Phosphate-3-Epimerase (RPE) (AA 1-228) antibody
RPE 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ribulose-5-Phosphate-3-Epimerase (RPE) (AA 1-228) antibodyRPE 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribulose-5-Phosphate-3-Epimerase (RPE) (AA 2-228) antibodyRPE 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribulose-5-Phosphate-3-Epimerase (RPE) (N-Term) antibodyRPE 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribulose-5-Phosphate-3-Epimerase (RPE) antibodyRPE 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Ribulose-5-Phosphate-3-Epimerase (RPE) (AA 35-84) antibodyRPE 适用: 人, Cow, 斑马鱼, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ribulose-5-Phosphate-3-Epimerase (RPE) (AA 71-120) antibodyRPE 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, Pig, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Ribulose-5-Phosphate-3-Epimerase (RPE) (N-Term) antibodyRPE 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the RPE antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the RPE Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- RPE (Ribulose-5-Phosphate-3-Epimerase (RPE))
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别名
- RPE
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背景
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RPE antibody targets Ribulose-phosphate 3-epimerase, encoded by the RPE gene. Ribulose-phosphate 3-epimerase is a cytosolic enzyme that plays an essential role in the non-oxidative phase of the pentose phosphate pathway. This metabolic pathway is critical for generating ribose-5-phosphate for nucleotide synthesis and for maintaining cellular redox balance through coordinated flux with NADPH-producing reactions. RPE catalyzes the reversible epimerization of ribulose-5-phosphate to xylulose-5-phosphate, enabling flexible carbon rearrangement to meet cellular biosynthetic demands.
Functionally, Ribulose-phosphate 3-epimerase supports cellular metabolism by facilitating the interconversion of pentose phosphates that feed into glycolysis and nucleotide biosynthesis. Through its enzymatic activity, RPE helps balance carbon flow between energy production and anabolic processes, particularly in rapidly dividing or metabolically active cells. The enzyme operates in concert with other pentose phosphate pathway components to adapt metabolic output in response to oxidative stress, nutrient availability, and proliferative signals. An RPE antibody supports studies focused on metabolic regulation and central carbon metabolism.
RPE is broadly expressed across tissues, reflecting the universal requirement for pentose phosphate pathway activity in mammalian cells. Expression is particularly relevant in tissues with high biosynthetic or detoxification capacity, such as liver and proliferative cell populations. As a housekeeping metabolic enzyme, RPE expression is relatively stable but can be modulated by metabolic state, cellular growth conditions, and stress responses that alter flux through the pentose phosphate pathway.
From a disease-relevance perspective, Ribulose-phosphate 3-epimerase has been studied in the context of cancer metabolism and cellular adaptation to oxidative stress. Altered pentose phosphate pathway activity is a hallmark of many tumors, where increased nucleotide demand and redox control support uncontrolled proliferation. Changes in RPE expression or regulation have therefore been examined as part of broader investigations into metabolic reprogramming in cancer and other diseases characterized by disrupted cellular metabolism.
At the molecular level, Ribulose-phosphate 3-epimerase is a conserved enzyme that functions as part of a tightly regulated metabolic network. Post-translational modifications, protein conformation, and cellular context can influence its enzymatic activity and electrophoretic behavior on SDS-PAGE without indicating changes in primary sequence. An RPE antibody supports research applications focused on metabolic enzyme expression, pentose phosphate pathway regulation, and disease-associated changes in cellular metabolism, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- Q96AT9
抗原
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