TCF12 抗体 (AA 67-300)
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北京 101111
Quick Overview for TCF12 抗体 (AA 67-300) (ABIN7876373)
抗原
See all TCF12 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 67-300
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原理
- TCF12 Antibody / Transcription factor 12
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human HEB/TCF12 recombinant protein (Position: S67-G300) was used as the immunogen for the TCF12 antibody.
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亚型
- IgG
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anti-Transcription Factor 12 (TCF12) (AA 364-453) antibody
TCF12 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 2E9 unconjugated
anti-Transcription Factor 12 (TCF12) (N-Term) antibodyTCF12 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor 12 (TCF12) (AA 443-682) antibodyTCF12 适用: 人 ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor 12 (TCF12) (N-Term) antibodyTCF12 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor 12 (TCF12) (N-Term) antibodyTCF12 适用: 人, 小鼠, Cow, Pig, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor 12 (TCF12) (N-Term) antibodyTCF12 适用: 人, 大鼠, 小鼠, Cow, 豚鼠, 犬, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor 12 (TCF12) (N-Term) antibodyTCF12 适用: 人, 大鼠, 小鼠, Cow, Pig, 小鸡, Hamster, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor 12 (TCF12) (AA 504-553) antibodyTCF12 适用: 人, 大鼠, 小鼠, Cow, 豚鼠, 犬, Pig, 马, Hamster, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor 12 (TCF12) (AA 1-50) antibodyTCF12 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TCF12 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TCF12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TCF12 (Transcription Factor 12 (TCF12))
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别名
- TCF12
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背景
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TCF12 antibody detects Transcription factor 12, encoded by the TCF12 gene. Transcription factor 12 is a basic helix-loop-helix transcription factor that regulates gene expression during development, differentiation, and tissue homeostasis. TCF12 antibody provides researchers with a specific reagent for studying transcriptional regulation, developmental pathways, and disease mechanisms involving abnormal transcription factor activity.
Transcription factor 12 dimerizes with other basic helix-loop-helix proteins to bind E-box DNA sequences and regulate gene transcription. Research using TCF12 antibody has shown that it partners with proteins such as E47, E12, and MyoD to control cell fate decisions. Through these interactions, TCF12 coordinates gene networks that drive muscle differentiation, neural development, and hematopoiesis.
Studies with TCF12 antibody have revealed that it is essential in neural crest development, craniofacial morphogenesis, and myogenesis. Mutations in the TCF12 gene cause craniosynostosis, a disorder characterized by premature fusion of cranial sutures. This highlights the importance of Transcription factor 12 in skeletal and craniofacial development. Its broad role in embryonic patterning underscores its significance in developmental biology.
In cancer research, dysregulation of TCF12 contributes to oncogenesis. Research using TCF12 antibody has shown that aberrant expression promotes epithelial-mesenchymal transition, migration, and invasion in cancers such as glioblastoma and colorectal carcinoma. By altering transcriptional programs, TCF12 contributes to tumor progression and poor clinical outcomes.
Beyond cancer, TCF12 has been linked to immune function. Studies with TCF12 antibody have revealed that it regulates lymphocyte development and differentiation. By controlling gene expression in immune progenitors, Transcription factor 12 ensures proper immune cell lineage commitment and functional competence. This expands its relevance to immunology.
TCF12 antibody is widely applied in chromatin immunoprecipitation, western blotting, and immunohistochemistry. Chromatin immunoprecipitation identifies DNA targets, western blotting quantifies protein expression, and immunohistochemistry reveals nuclear localization in tissue. These approaches make TCF12 antibody a versatile tool in developmental and disease biology.
By supplying validated TCF12 antibody reagents, NSJ Bioreagents supports studies into transcriptional control, development, and pathology. Detection of Transcription factor 12 provides researchers with insight into how helix-loop-helix proteins regulate gene expression across diverse biological systems. -
UniProt
- Q99081
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途径
- SARS-CoV-2 Protein Interactome
抗原
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