GIPC1 抗体 (AA 66-333)
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Quick Overview for GIPC1 抗体 (AA 66-333) (ABIN7876339)
抗原
See all GIPC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 66-333
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原理
- GIPC1 Antibody / PDZ domain-containing protein GIPC1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GIPC1 recombinant protein (Position: H66-Y333) was used as the immunogen for the GIPC1 antibody.
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亚型
- IgG
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anti-GIPC PDZ Domain Containing Family, Member 1 (GIPC1) (AA 7-74) antibody
GIPC1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-GIPC PDZ Domain Containing Family, Member 1 (GIPC1) antibodyKD Validated GIPC1 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB6645 unconjugated
anti-GIPC PDZ Domain Containing Family, Member 1 (GIPC1) antibodyGIPC1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-GIPC PDZ Domain Containing Family, Member 1 (GIPC1) (AA 61-158) antibodyGIPC1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-GIPC PDZ Domain Containing Family, Member 1 (GIPC1) (C-Term) antibodyVerified GIPC1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-GIPC PDZ Domain Containing Family, Member 1 (GIPC1) (AA 40-89) antibodyGIPC1 适用: 人, 小鼠, 大鼠, 斑马鱼, Cow, 犬, 豚鼠, Bat, Hamster, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GIPC PDZ Domain Containing Family, Member 1 (GIPC1) antibodyKD Validated GIPC1 适用: 人 WB 宿主: 小鼠 Monoclonal 24GB6650 unconjugated
anti-GIPC PDZ Domain Containing Family, Member 1 (GIPC1) (C-Term) antibodyGIPC1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GIPC PDZ Domain Containing Family, Member 1 (GIPC1) (AA 10-24), (Intracellular) antibodyGIPC1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-GIPC PDZ Domain Containing Family, Member 1 (GIPC1) (AA 101-160) antibodyGIPC1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GIPC1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GIPC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GIPC1 (GIPC PDZ Domain Containing Family, Member 1 (GIPC1))
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别名
- GIPC1
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背景
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GIPC1 antibody detects PDZ domain-containing protein GIPC1, a cytoplasmic adaptor protein that regulates receptor trafficking, cell signaling, and cytoskeletal organization. The UniProt recommended name is PDZ domain-containing protein GIPC1 (GIPC1). This multifunctional scaffold protein interacts with a wide variety of transmembrane receptors, G-protein coupled receptors, and signaling adaptors through its conserved PDZ domain, influencing signal transduction and vesicular transport.
Functionally, GIPC1 antibody identifies a 333-amino-acid protein that contains a central PDZ domain responsible for binding the C-terminal motifs of target proteins such as TGFbeta receptor III, GLUT1, and neuropilin-1. GIPC1 participates in endocytic recycling and intracellular trafficking of these receptors, thereby modulating cellular responses to growth factors, adhesion molecules, and hormones. Additionally, GIPC1 acts as a linker between membrane receptors and the actin cytoskeleton via interactions with myosin VI, regulating cell polarity and motility.
The GIPC1 gene is located on chromosome 19p13.12 and is expressed ubiquitously, with high levels found in epithelial, neuronal, and endothelial tissues. Its expression is regulated during development and by extracellular stimuli such as growth factors and oxidative stress. GIPC1 is essential for maintaining proper vesicle transport and receptor localization in diverse cell types.
Pathologically, altered GIPC1 expression has been implicated in cancer progression, angiogenesis, and neurological disorders. Overexpression in breast, pancreatic, and gastric cancers enhances tumor cell proliferation and migration by stabilizing growth factor receptor signaling. In neurons, dysregulated GIPC1 may disrupt synaptic vesicle trafficking and signaling. Research using GIPC1 antibody supports studies in receptor trafficking, cancer signaling, and cytoskeletal regulation.
GIPC1 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect adaptor proteins involved in signal transduction. NSJ Bioreagents provides GIPC1 antibody reagents optimized for research in receptor recycling, endocytosis, and actin-coupled signaling pathways.
Structurally, PDZ domain-containing protein GIPC1 includes an N-terminal GH1 domain for dimerization, a central PDZ domain for C-terminal binding to target proteins, and a C-terminal GH2 domain for myosin VI interaction. This modular structure enables GIPC1 to act as a versatile scaffold that coordinates endocytic transport and receptor-mediated signaling. This antibody enables exploration of GIPC1's role in intracellular trafficking, cancer progression, and signal compartmentalization. -
UniProt
- O14908
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途径
- Dicarboxylic Acid Transport
抗原
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