ORC1 抗体 (AA 628-861)
Our Local Distributor
北京 101111
Quick Overview for ORC1 抗体 (AA 628-861) (ABIN7876203)
抗原
See all ORC1 (ORC1L) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 628-861
-
原理
- ORC1 Antibody / Origin Recognition Complex 1
-
纯化方法
- Antigen affinity purified
-
免疫原
- E. coli-derived recombinant human protein (amino acids H628-E861) was used as the immunogen for the ORC1 antibody.
-
亚型
- IgG
-
-
anti-Origin Recognition Complex, Subunit 1 (ORC1L) antibody
ORC1L 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Origin Recognition Complex, Subunit 1 (ORC1L) (AA 1-110) antibodyORC1L 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3H1 unconjugated
anti-Origin Recognition Complex, Subunit 1 (ORC1L) (Internal Region) antibodyORC1L 适用: 人 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Origin Recognition Complex, Subunit 1 (ORC1L) antibodyORC1L 适用: 人 WB, IP 宿主: 大鼠 Monoclonal 7A7 unconjugated
anti-Origin Recognition Complex, Subunit 1 (ORC1L) (AA 1-110) antibodyORC1L 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Origin Recognition Complex, Subunit 1 (ORC1L) (AA 170-220) antibodyORC1L 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Origin Recognition Complex, Subunit 1 (ORC1L) antibodyORC1L 适用: 人 ELISA 宿主: 小鼠 Monoclonal 7F6-1 unconjugated
anti-Origin Recognition Complex, Subunit 1 (ORC1L) (AA 696-856) antibodyORC1L 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Origin Recognition Complex, Subunit 1 (ORC1L) (AA 628-861) antibodyORC1L 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the ORC1 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the ORC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))
-
别名
- ORC1
-
背景
- Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
-
UniProt
- Q13415
-
途径
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
抗原
-
