LUZP1 抗体 (AA 604-1040)
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北京 101111
Quick Overview for LUZP1 抗体 (AA 604-1040) (ABIN7876073)
抗原
See all LUZP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 604-1040
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原理
- LUZP1 Antibody / Leucine zipper protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human LUZP1 recombinant protein (Position: K604-H1040) was used as the immunogen for the LUZP1 antibody.
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亚型
- IgG
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anti-Leucine Zipper Protein 1 (LUZP1) (AA 1042-1070), (C-Term) antibody
LUZP1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB24935 unconjugated
anti-Leucine Zipper Protein 1 (LUZP1) (AA 1-50) antibodyLUZP1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Leucine Zipper Protein 1 (LUZP1) (N-Term) antibodyLUZP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the LUZP1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the LUZP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- LUZP1 (Leucine Zipper Protein 1 (LUZP1))
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别名
- LUZP1
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背景
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LUZP1 antibody detects Leucine zipper protein 1, encoded by the LUZP1 gene on chromosome 1p36.13. LUZP1 antibody is used in studies of this multifunctional nuclear and cytoskeletal protein, which contains leucine zipper motifs that mediate protein-protein interactions and coiled-coil structures. LUZP1 is widely expressed in developing tissues and adult organs, with notable abundance in brain, heart, and skeletal muscle. Its diverse localizations and interaction partners suggest roles in transcriptional regulation, actin cytoskeleton organization, and cell cycle progression.
Structurally, LUZP1 consists of multiple leucine zipper domains, which allow dimerization and interactions with transcription factors and chromatin modifiers. In addition, LUZP1 contains nuclear localization signals and regions that associate with actin filaments, positioning it at the interface of nuclear and cytoskeletal regulation. Its dynamic shuttling between the nucleus and cytoplasm highlights its multifunctionality. Studies suggest LUZP1 is involved in regulating gene transcription by interacting with chromatin remodeling complexes and transcriptional activators.
Functionally, LUZP1 has been linked to embryonic development and neuronal differentiation. Knockdown experiments in zebrafish and mouse models indicate that reduced LUZP1 expression disrupts neural tube closure and brain patterning, consistent with its role in neural crest cell migration. In muscle, LUZP1 influences actin filament organization and may stabilize sarcomere structures. In cancer biology, LUZP1 dysregulation has been reported in glioblastoma, hepatocellular carcinoma, and breast cancer, where it may function as a tumor suppressor by antagonizing proliferative signaling pathways. Researchers use LUZP1 antibody to investigate its contributions to developmental processes and oncogenesis.
Clinically, LUZP1 mutations and altered expression are associated with congenital brain malformations and neurodevelopmental syndromes. Transcriptomic analyses reveal that LUZP1 downregulation is linked to poor prognosis in some cancers, possibly through disruption of actin cytoskeleton dynamics and transcriptional repression. Recent work suggests LUZP1 modulates Wnt signaling and other pathways important for proliferation and differentiation. The ability of LUZP1 to interact with multiple partners underlines its versatility as a scaffold protein and transcriptional regulator.
Experimentally, LUZP1 antibody is applied in western blotting to detect the ~110 kDa protein, in immunofluorescence to highlight nuclear and cytoskeletal localization, and in immunohistochemistry to evaluate expression in tumor tissues. Co-immunoprecipitation with LUZP1 antibody has identified binding partners including transcriptional co-repressors and actin-regulatory proteins. These findings point to its dual role in gene regulation and cytoskeletal remodeling. NSJ Bioreagents provides LUZP1 antibody to support researchers in developmental biology, neuroscience, and cancer biology, ensuring high-quality detection of this leucine zipper protein. -
UniProt
- Q86V48
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途径
- Tube Formation
抗原
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