Recombinant L1CAM 抗体 (AA 600-900)
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Quick Overview for Recombinant L1CAM 抗体 (AA 600-900) (ABIN7876059)
抗原
See all L1CAM 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 600-900
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原理
- Recombinant CD171 Antibody / NCAM-L1 / L1CAM
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant fragment (within amino acids 600-900) of human L1CAM protein was used as the immunogen for the recombinant CD171 antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the recombinant CD171 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant CD171 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- L1CAM (L1 Cell Adhesion Molecule (L1CAM))
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别名
- CD171
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背景
- L1 (L1 cell adhesion molecule) also known as CAML1, CD171, and HSAS is an adhesion molecule which plays an important role in the nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). This mouse monoclonal antibody recognizes the sequence immediately NH2-terminal to the tyrosine-based motif and binds L1 only when Y1176 is dephosphorylated. Phosphorylation of either T1172 or Y1176 strongly inhibits binding of 74-5H7 to the L1 cytoplasmic domain.
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UniProt
- P32004
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途径
- Synaptic Membrane
抗原
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