POC1A 抗体 (AA 6-371)
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Quick Overview for POC1A 抗体 (AA 6-371) (ABIN7875960)
抗原
See all POC1A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 6-371
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原理
- POC1A Antibody / POC1 centriolar protein A
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human POC1A recombinant protein (Position: A6-D371) was used as the immunogen for the POC1A antibody.
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亚型
- IgG
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anti-POC1 Centriolar Protein Homolog A (POC1A) (AA 138-407) antibody
POC1A 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-POC1 Centriolar Protein Homolog A (POC1A) (AA 326-360), (C-Term) antibodyPOC1A 适用: 人 WB 宿主: 兔 Polyclonal RB49679 unconjugated
anti-POC1 Centriolar Protein Homolog A (POC1A) (AA 1-364) antibodyPOC1A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-POC1 Centriolar Protein Homolog A (POC1A) (AA 34-61), (N-Term) antibodyPOC1A 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB37964 unconjugated
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应用备注
- Optimal dilution of the POC1A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the POC1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- POC1A (POC1 Centriolar Protein Homolog A (POC1A))
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别名
- POC1A
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背景
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POC1A antibody detects POC1 centriolar protein A, a core structural component of centrioles essential for their assembly, stability, and duplication. POC1A belongs to a conserved family of centriolar proteins that maintain centrosome integrity and regulate spindle formation during mitosis. The POC1A antibody is widely used in cell cycle, ciliogenesis, and developmental biology research to study centrosome organization and division control.
POC1A is encoded by the POC1A gene located on human chromosome 3p21.2. The protein is approximately 45 kilodaltons and contains an N-terminal WD40 domain that mediates protein-protein interactions and a C-terminal coiled-coil region required for centriolar localization. POC1A localizes to the proximal ends of centrioles and basal bodies, where it contributes to centriole duplication fidelity and stability.
The POC1A antibody detects a 45 kilodalton band in western blot assays and shows centrosomal staining in interphase and mitotic cells. POC1A is required for the maintenance of mature centrioles and proper spindle orientation during cell division. It works in concert with other centriolar components, including CEP135 and SAS6, ensuring correct microtubule organization and ciliogenesis.
Mutations in POC1A cause primordial dwarfism and growth retardation syndromes due to defective centriole biogenesis and impaired mitotic progression. Cells lacking POC1A exhibit abnormal centrosome numbers, fragmented spindles, and cell cycle arrest. POC1A expression is also implicated in cilia assembly, linking centrosome function to signaling pathways such as Hedgehog and Wnt.
Because of its importance in centrosome biology, POC1A serves as a useful marker for studying mitotic structures, developmental abnormalities, and ciliopathies. NSJ Bioreagents provides a validated POC1A antibody optimized for western blot, immunofluorescence, and centrosome imaging, supporting research into centriole duplication, ciliary formation, and cell division regulation. -
UniProt
- Q8NBT0
抗原
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