FBXO32 抗体 (AA 6-355)
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Quick Overview for FBXO32 抗体 (AA 6-355) (ABIN7875957)
抗原
See all FBXO32 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 6-355
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原理
- FBXO32 Antibody / F-box only protein 32 / Atrogin 1
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纯化方法
- Antigen affinity purified
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免疫原
- An E.coli-derived human recombinant protein (amino acids Q6-F355) was used as the immunogen for the FBXO32 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the FBXO32 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the FBXO32 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- FBXO32 (F-Box Protein 32 (FBXO32))
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别名
- FBXO32
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背景
- F-box only protein 32, also known as MAFbx, for Muscle Atrophy F-box gene, and Atrogin-1, is a protein that in humans is encoded by the FBXO32 gene. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
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UniProt
- Q969P5
抗原
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