Recombinant Ferritin 抗体 (Heavy Chain)
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Quick Overview for Recombinant Ferritin 抗体 (Heavy Chain) (ABIN7875842)
抗原
See all Ferritin (FE) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 58-180, Heavy Chain
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原理
- Recombinant Ferritin Heavy Chain Antibody / FTH1
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant human FTH1 protein fragment (within amino acids 58-180) was used as the immunogen for the recombinant Ferritin Heavy Chain antibody.
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亚型
- IgG, kappa
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anti-Ferritin (FE) antibody
FE 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Ferritin (FE) antibodyKD Validated FE 适用: 人, 小鼠, 大鼠 WB, ICC, IF 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the recombinant Ferritin Heavy Chain antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant Ferritin Heavy Chain antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Ferritin (FE)
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别名
- Ferritin
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背景
- Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidationof FeI(II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of aging-related cataracts.
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UniProt
- P02794
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途径
- Transition Metal Ion Homeostasis
抗原
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