DGCR8 抗体 (AA 570-771)
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Quick Overview for DGCR8 抗体 (AA 570-771) (ABIN7875818)
抗原
See all DGCR8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 570-771
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原理
- Zebrafish Dgcr8 Antibody
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Dgcr8 recombinant protein (amino acids K570-Q771) was used as the immunogen for the Zebrafish Dgcr8 antibody.
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亚型
- Ig Fraction
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anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) antibody
KD Validated DGCR8 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB1615 unconjugated Recombinant Antibody
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 675-771) antibodyDGCR8 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4G3 unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 1-773) antibodyDGCR8 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 1-773) antibodyDGCR8 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 1-773) antibodyDGCR8 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 675-771) antibodyDGCR8 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 180-229) antibodyDGCR8 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (C-Term) antibodyDGCR8 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) antibodyDGCR8 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 439-466) antibodyDGCR8 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB21435 unconjugated
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应用备注
- Optimal dilution of the Zebrafish Dgcr8 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Dgcr8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
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别名
- Dgcr8
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背景
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Dgcr8, or DiGeorge syndrome critical region gene eight, is a double stranded RNA binding protein that plays a key role in the microRNA processing pathway. In zebrafish, Dgcr8 is an essential component of the microprocessor complex, which includes the ribonuclease enzyme Drosha. Together, they initiate the first step in converting primary microRNA transcripts into precursor microRNAs, which are further processed into mature microRNAs.
MicroRNAs are short noncoding RNAs that regulate gene expression by targeting messenger RNAs for degradation or translational repression. Dgcr8 is crucial for maintaining proper levels of microRNAs, which are involved in numerous biological processes including early development, cell differentiation, neurogenesis, and organ formation.
In zebrafish, Dgcr8 is expressed during early embryogenesis and is required for normal development of the brain, heart, and other organs. Loss of Dgcr8 function results in widespread defects due to disrupted microRNA biogenesis. Because of its evolutionary conservation and central role in RNA regulation, zebrafish Dgcr8 is widely used in studies of gene expression control, developmental biology, and disease models related to microRNA dysfunction.
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UniProt
- A2BEG3
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途径
- Regulatory RNA Pathways
抗原
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