STOX2 抗体 (AA 57-659)
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北京 101111
Quick Overview for STOX2 抗体 (AA 57-659) (ABIN7875810)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 57-659
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原理
- STOX2 Antibody / Storkhead box protein 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human STOX2 recombinant protein (Position: D57-K659) was used as the immunogen for the STOX2 antibody.
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亚型
- IgG
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anti-Storkhead Box 2 (STOX2) (AA 57-659) antibody
STOX2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Storkhead Box 2 (STOX2) (C-Term) antibodySTOX2 适用: 人, 小鼠, 大鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
anti-Storkhead Box 2 (STOX2) (C-Term) antibodySTOX2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the STOX2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the STOX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- STOX2 (Storkhead Box 2 (STOX2))
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别名
- STOX2
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背景
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STOX2 antibody detects Storkhead box protein 2, a nuclear transcription factor encoded by the STOX2 gene located on chromosome 4q35.1. STOX2 belongs to the storkhead box protein family, characterized by winged-helix (forkhead-like) DNA-binding domains, and functions primarily in transcriptional regulation during embryonic development and placental differentiation. It is expressed in brain, placenta, and reproductive tissues, with developmental expression patterns suggesting a key role in early organogenesis and epithelial cell specification.
STOX2 regulates gene networks involved in cell differentiation, extracellular matrix formation, and immune modulation. As a nuclear transcription factor, it binds promoter and enhancer regions to modulate expression of developmental and hormonal response genes. STOX2 expression increases during embryogenesis and trophoblast development, indicating a function in maternal-fetal interface establishment. In adult tissues, it remains expressed in epithelial and endothelial cells, maintaining homeostasis and tissue-specific gene expression.
Structurally, STOX2 contains a winged-helix DNA-binding domain typical of forkhead-like transcription factors, along with transactivation domains in its C-terminus that recruit transcriptional coactivators. It belongs to the storkhead box protein family, which includes STOX1i 1/2a transcription factor associated with preeclampsiai 1/2highlighting shared regulatory mechanisms in placental and vascular development. STOX2 may co-localize with transcriptional regulators such as SMADs in TGF-beta signaling, influencing epithelial differentiation and growth factor response.
Functionally, STOX2 contributes to placental morphogenesis and vascular remodeling. Its regulatory role in epithelial-mesenchymal transitions (EMT) and matrix deposition suggests involvement in tissue remodeling and wound repair. STOX2 may also modulate immune tolerance mechanisms at the maternal-fetal interface, ensuring proper placental development. In the nervous system, developmental expression studies show STOX2 activity during neuronal lineage specification, indicating broader roles beyond placentation.
Dysregulation of STOX2 expression has been associated with pregnancy-related disorders such as preeclampsia and intrauterine growth restriction. Aberrant promoter methylation or altered transcriptional regulation can disrupt placental gene networks. In cancer, reduced STOX2 levels have been linked to loss of epithelial integrity, while overexpression may contribute to tumor invasion through EMT activation. Pathway associations include TGF-beta signaling, Wnt signaling, and gene regulatory pathways governing developmental morphogenesis.
STOX2 antibody from NSJ Bioreagents serves as a reliable tool for investigating developmental transcriptional regulation, placental biology, and disease mechanisms involving epithelial differentiation. -
UniProt
- Q9P2F5
抗原
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