STXBP4 抗体 (AA 57-481)
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Quick Overview for STXBP4 抗体 (AA 57-481) (ABIN7875808)
抗原
See all STXBP4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 57-481
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原理
- STXBP4 Antibody / Syntaxin-binding protein 4
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纯化方法
- Affinity purified
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免疫原
- Amino acids D57-E481 from the human protein were used as the immunogen for the STXBP4 antibody.
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亚型
- IgG
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anti-Syntaxin Binding Protein 4 (STXBP4) (AA 1-245) antibody
STXBP4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B12 unconjugated
anti-Syntaxin Binding Protein 4 (STXBP4) antibodySTXBP4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin Binding Protein 4 (STXBP4) (AA 344-553) antibodySTXBP4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin Binding Protein 4 (STXBP4) (AA 57-481) antibodySTXBP4 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin Binding Protein 4 (STXBP4) (N-Term) antibodySTXBP4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the STXBP4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the STXBP4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- STXBP4 (Syntaxin Binding Protein 4 (STXBP4))
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别名
- STXBP4
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背景
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STXBP4 antibody is used in research to study cellular trafficking and membrane dynamics. The encoded protein, syntaxin-binding protein 4, belongs to the Sec1/Munc18 family, which plays an essential role in the regulation of SNARE-mediated vesicle fusion. STXBP4 interacts with syntaxins to control the docking and fusion of vesicles with target membranes, a process fundamental to intracellular transport, receptor recycling, and signal transduction. Through its role in vesicular trafficking, STXBP4 contributes to the maintenance of cellular polarity, nutrient uptake, and receptor turnover.
STXBP4 is particularly significant in processes related to glucose metabolism. It has been shown to regulate the trafficking of the glucose transporter GLUT4 to the plasma membrane in muscle and adipose tissue. This regulation is critical for insulin-stimulated glucose uptake, linking STXBP4 directly to metabolic homeostasis. Alterations in its expression or activity have been connected to insulin resistance and type 2 diabetes, making it an important subject of investigation in metabolic disease research. Beyond glucose regulation, STXBP4 participates in broader endocytic and exocytic pathways that influence receptor signaling and cellular communication.
Studies suggest that STXBP4 may also contribute to cancer biology. Dysregulated expression has been observed in certain tumor types, where altered vesicle trafficking can affect growth factor signaling and proliferation. Research is ongoing to determine whether STXBP4 serves as a biomarker for cancer progression or a potential therapeutic target. Its involvement in vesicle-mediated signaling suggests that it may influence multiple pathways central to tumor growth and survival.
At the molecular level, STXBP4 is characterized by conserved domains that enable binding to syntaxins and interaction with SNARE complexes. This interaction stabilizes vesicle docking and coordinates the timing of fusion events. Experimental models demonstrate that modulation of STXBP4 can alter the efficiency of GLUT4 vesicle fusion, highlighting its central role in metabolic regulation. Antibody-based approaches are frequently used to assess protein levels, localization, and interactions within these pathways.
The STXBP4 antibody is widely applied in techniques such as western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. These applications allow scientists to investigate expression across tissues, examine subcellular distribution, and evaluate changes in disease states. When used alongside functional assays, STXBP4 detection provides valuable insight into vesicle trafficking and its consequences for metabolism and signaling. For investigators examining insulin action, metabolic disorders, or vesicular transport, the STXBP4 antibody is a reliable and versatile research tool. NSJ Bioreagents offers carefully validated antibodies to ensure reproducibility and accuracy in advanced scientific studies. -
UniProt
- Q6ZWJ1
抗原
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