SMYD1 抗体 (AA 57-472)
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Quick Overview for SMYD1 抗体 (AA 57-472) (ABIN7875807)
抗原
See all SMYD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 57-472
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原理
- SMYD1 Antibody / SET and MYND domain-containing protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SMYD1 recombinant protein (Position: K57-Q472) was used as the immunogen for the SMYD1 antibody.
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亚型
- IgG
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anti-SET and MYND Domain Containing 1 (SMYD1) (AA 1-350) antibody
SMYD1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SET and MYND Domain Containing 1 (SMYD1) (AA 420-449), (C-Term) antibodySMYD1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB20548 unconjugated
anti-SET and MYND Domain Containing 1 (SMYD1) (AA 31-130) antibodySMYD1 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-SET and MYND Domain Containing 1 (SMYD1) (AA 395-444) antibodySMYD1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, Pig, 猴, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-SET and MYND Domain Containing 1 (SMYD1) (AA 107-156) antibodySMYD1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-SET and MYND Domain Containing 1 (SMYD1) (N-Term) antibodySMYD1 适用: 小鼠, 大鼠, 犬, 豚鼠, 兔, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-SET and MYND Domain Containing 1 (SMYD1) (N-Term) antibodySMYD1 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-SET and MYND Domain Containing 1 (SMYD1) (AA 420-449), (C-Term) antibodySMYD1 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SMYD1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SMYD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SMYD1 (SET and MYND Domain Containing 1 (SMYD1))
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别名
- SMYD1
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背景
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SMYD1 antibody detects SET and MYND domain-containing protein 1, a muscle-specific histone methyltransferase that regulates gene expression during cardiac and skeletal muscle differentiation. SMYD1 modulates transcription by methylating histone H3 on lysine 4 and recruiting transcriptional cofactors to promoter regions of muscle-specific genes. The SMYD1 antibody is widely used in developmental biology and epigenetics research to study muscle gene regulation, histone modification, and cardiogenesis.
SMYD1 is encoded by the SMYD1 gene located on human chromosome 2p11.2. The protein is approximately 490 amino acids long and contains an N-terminal SET domain responsible for methyltransferase activity and a C-terminal MYND zinc-finger domain that mediates protein-protein interactions. SMYD1 is predominantly expressed in heart and skeletal muscle tissues, where it coordinates transcriptional programs required for myofibril assembly and contractile function.
The SMYD1 antibody detects a 55 kilodalton band by western blot and shows nuclear and sarcoplasmic staining under immunofluorescence microscopy. SMYD1 acts as a transcriptional regulator of genes encoding structural and contractile proteins such as myosin heavy chains and troponins. It interacts with cofactors like HDACs and skNAC to coordinate repression and activation cycles during myogenesis.
Loss of SMYD1 function in animal models results in defective cardiac morphogenesis, reduced sarcomere organization, and embryonic lethality, highlighting its critical developmental role. Dysregulation of SMYD1 expression has been linked to cardiomyopathy and muscular dystrophy, where abnormal histone methylation alters muscle gene networks. Beyond muscle, SMYD1 may influence differentiation of smooth muscle and endothelial lineages through epigenetic signaling.
Because SMYD1 couples chromatin modification to tissue-specific transcription, it represents a pivotal regulator of muscle differentiation and cardiac development. NSJ Bioreagents provides a validated SMYD1 antibody optimized for its applications, supporting research into epigenetic control, muscle biology, and developmental gene regulation. -
UniProt
- Q8NB12
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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