Emerin 抗体 (AA 56-167)
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北京 101111
Quick Overview for Emerin 抗体 (AA 56-167) (ABIN7875758)
抗原
See all Emerin (EMD) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 56-167
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原理
- Emerin Antibody
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纯化方法
- Protein G affinity chromatography
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免疫原
- A portion of amino acids 56-167 from the human protein was used as the immunogen for the Emerin antibody.
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亚型
- IgG2b, kappa
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应用备注
- Titering of the Emerin antibody may be required for optimal performance.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the Emerin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- Emerin (EMD)
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别名
- Emerin
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背景
- Emerin is a member of the nuclear lamina associated protein family. It is ubiquitously expressed and localized to the nuclear membrane in normal cells. Mutations of the gene that encodes emerin result in the X-linked recessive disease Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by slowly progressing contractures, skeletal muscle wasting and cardiomyopathy. Reportedly, lack of Emerin expression is one cause of EDMD. Emerin is involved in the association of the nuclear membrane with the lamina, and is localized specifically to desmosomes and fasciae adherents in the heart. Identification of nuclear membrane irregularities with anti-emerin antibody has been reported useful in diagnosing papillary thyroid carcinoma.
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UniProt
- P50402
抗原
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