GRK5 抗体 (AA 559-590)
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Quick Overview for GRK5 抗体 (AA 559-590) (ABIN7875753)
抗原
See all GRK5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 559-590
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原理
- GRK5 Antibody / G protein-coupled receptor kinase 5
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 559-590 from the human protein as used as the immunogen for the GRK5 antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the GRK5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the GRK5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- GRK5 (G Protein-Coupled Receptor Kinase 5 (GRK5))
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别名
- GRK5
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背景
- Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).
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UniProt
- P34947
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途径
- Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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