TUSC1 抗体 (AA 54-209)
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北京 101111
Quick Overview for TUSC1 抗体 (AA 54-209) (ABIN7875647)
抗原
See all TUSC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 54-209
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原理
- TUSC1 Antibody / Tumor suppressor candidate 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TUSC1 recombinant protein (Position: A54-L209) was used as the immunogen for the TUSC1 antibody.
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亚型
- IgG
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anti-Tumor Suppressor Candidate 1 (TUSC1) antibody
TUSC1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Suppressor Candidate 1 (TUSC1) antibodyTUSC1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Suppressor Candidate 1 (TUSC1) (AA 31-64) antibodyTUSC1 适用: 小鼠, 人 WB 宿主: 兔 Polyclonal RB55076 unconjugated
anti-Tumor Suppressor Candidate 1 (TUSC1) (AA 108-141) antibodyTUSC1 适用: 人 WB 宿主: 兔 Polyclonal RB53983 unconjugated
anti-Tumor Suppressor Candidate 1 (TUSC1) (C-Term) antibodyTUSC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tumor Suppressor Candidate 1 (TUSC1) (Middle Region) antibodyTUSC1 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Tumor Suppressor Candidate 1 (TUSC1) (AA 111-138) antibodyTUSC1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40185 unconjugated
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应用备注
- Optimal dilution of the TUSC1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TUSC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TUSC1 (Tumor Suppressor Candidate 1 (TUSC1))
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别名
- TUSC1
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背景
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TUSC1 antibody detects Tumor suppressor candidate 1, encoded by the TUSC1 gene on chromosome 9p21. TUSC1 antibody is widely used to study this protein, originally identified in lung cancer research as part of a genomic region frequently deleted in tumors. Although not fully characterized biochemically, TUSC1 is strongly implicated as a tumor suppressor, participating in cell cycle regulation, apoptosis, and maintenance of genomic stability. Its expression pattern across tissues and frequent inactivation in cancers highlight its importance in normal growth control and oncogenesis.
Structurally, TUSC1 encodes a small cytoplasmic and nuclear protein with predicted coiled-coil regions that may serve as scaffolding modules. These domains suggest potential roles in mediating protein-protein interactions and stabilizing regulatory complexes. Despite lacking enzymatic motifs, TUSC1 likely influences signaling pathways indirectly by modulating the activity of other proteins or transcriptional regulators. Subcellular fractionation studies show that TUSC1 can shuttle between the nucleus and cytoplasm, further broadening its regulatory potential.
Functionally, TUSC1 acts as a negative regulator of cell growth. Studies demonstrate that cells lacking TUSC1 exhibit increased proliferation, while reintroduction suppresses colony formation in vitro and tumor growth in xenograft models. TUSC1 has been associated with activation of apoptotic pathways, possibly by facilitating mitochondrial apoptotic signaling and caspase activation. Its ability to influence both cell cycle and apoptosis highlights its tumor suppressor characteristics. Researchers use TUSC1 antibody to investigate expression changes between normal and malignant tissues, particularly in lung, ovarian, renal, and brain cancers.
Clinically, deletions or reduced expression of TUSC1 are observed in non-small cell lung carcinoma and multiple other tumors. Mechanistically, loss of TUSC1 often occurs through chromosomal deletion of 9p21, a locus that also contains CDKN2A, another tumor suppressor gene. Epigenetic silencing via promoter hypermethylation has been reported, adding another layer of regulation. Clinical studies suggest that TUSC1 status may correlate with prognosis, with low expression linked to more aggressive tumor phenotypes. Restoration of TUSC1 in cancer cell models increases sensitivity to chemotherapy and radiation, highlighting its therapeutic potential.
Beyond oncology, TUSC1 may also influence development and tissue homeostasis. Animal studies show tissue-specific expression during embryogenesis, suggesting developmental roles that remain underexplored. Transcriptomic data indicate potential involvement in neuronal pathways, though further research is needed. These diverse associations make TUSC1 an appealing target for continued study. NSJ Bioreagents supplies TUSC1 antibody as a reliable reagent for cancer research, molecular biology, and developmental studies. -
UniProt
- Q2TAM9
抗原
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