ORMDL3 抗体 (AA 53-81)
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Quick Overview for ORMDL3 抗体 (AA 53-81) (ABIN7875600)
抗原
See all ORMDL3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 53-81
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原理
- ORMDL3 Antibody / ORM1-like protein 3
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纯化方法
- Antigen affinity
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免疫原
- A portion of amino acids 53-81 from the human protein was used as the immunogen for the ORMDL3 antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the ORMDL3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the ORMDL3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- ORMDL3 (ORM1-Like 3 (ORMDL3))
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别名
- ORMDL3
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背景
- ORM1-like protein 3 is a protein that is encoded by the ORMDL3 gene. It belongs to a family of proteins known as ORM proteins, which play a crucial role in regulating the levels of sphingolipids - a class of lipids that are involved in various cellular processes. In particular, ORMDL3 has been shown to be a key player in the regulation of sphingolipid synthesis, and aberrant expression of this protein has been implicated in a number of diseases, including asthma. Recent studies have revealed that ORMDL3 plays a critical role in the development of asthma. It has been shown that individuals with certain genetic variations that result in increased ORMDL3 expression are at a higher risk of developing asthma. Additionally, ORMDL3 has been shown to be involved in the regulation of immune responses in the lungs, with increased levels of this protein leading to inflammation and airway hyperreactivity - hallmark features of asthma.
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UniProt
- Q8N138
抗原
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