ASXL1 抗体 (AA 521-549)
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Quick Overview for ASXL1 抗体 (AA 521-549) (ABIN7875580)
抗原
See all ASXL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 521-549
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原理
- Additional sex combs-like protein 1 Antibody / ASXL1
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 521-549 from the human protein was used as the immunogen for the Additional sex combs-like protein 1 antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Additional sex combs-like protein 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Additional sex combs-like protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- ASXL1 (Additional Sex Combs Like 1 (ASXL1))
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别名
- Additional sex combs-like protein 1
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背景
- This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.
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UniProt
- Q8IXJ9
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途径
- Retinoic Acid Receptor Signaling Pathway
抗原
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