COMT 抗体 (AA 52-271)
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Quick Overview for COMT 抗体 (AA 52-271) (ABIN7875555)
抗原
See all COMT 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 52-271
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原理
- COMT Antibody
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纯化方法
- Affinity purified
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免疫原
- A human recombinant protein (amino acids G52-P271) was used as the immunogen for the COMT antibody.
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亚型
- IgG2b
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应用备注
- Optimal dilution of the COMT antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the COMT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- COMT (Catechol-O-Methyltransferase (COMT))
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别名
- COMT
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背景
- Catechol O-methyltransferase, also called COMT, is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines. This gene is mapped to 22q11.21. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini.
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UniProt
- P21964
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途径
- Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interactome
抗原
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