HBP1 抗体 (AA 51-506)
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北京 101111
Quick Overview for HBP1 抗体 (AA 51-506) (ABIN7875522)
抗原
See all HBP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 51-506
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原理
- HBP1 Antibody / HMG-box transcription factor 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human HBP1 recombinant protein (Position: D51-R506) was used as the immunogen for the HBP1 antibody.
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亚型
- IgG
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anti-HMG Box-Containing Protein 1 (HBP1) (AA 421-514) antibody
HBP1 适用: 小鼠 WB, ELISA, IHC (p), ICC, IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-HMG Box-Containing Protein 1 (HBP1) (C-Term) antibodyHBP1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-HMG Box-Containing Protein 1 (HBP1) (AA 1-514) antibodyHBP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-HMG Box-Containing Protein 1 (HBP1) (C-Term) antibodyHBP1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-HMG Box-Containing Protein 1 (HBP1) (C-Term) antibodyHBP1 适用: 人, 小鼠, 大鼠, Cow, 犬, 猴, 豚鼠, 小鸡, 马, 兔, 非洲爪蟾, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-HMG Box-Containing Protein 1 (HBP1) (AA 396-445) antibodyHBP1 适用: 人, 大鼠, 犬, 猴, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-HMG Box-Containing Protein 1 (HBP1) (Middle Region) antibodyHBP1 适用: 人, 小鼠, 大鼠, Cow, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-HMG Box-Containing Protein 1 (HBP1) (Middle Region) antibodyHBP1 适用: 人, 小鼠, 大鼠, Cow, 犬, 小鸡, 斑马鱼, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-HMG Box-Containing Protein 1 (HBP1) (N-Term) antibodyHBP1 适用: 人, 小鼠, 大鼠, Cow, 犬, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-HMG Box-Containing Protein 1 (HBP1) (pSer402) antibodyHBP1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the HBP1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the HBP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- HBP1 (HMG Box-Containing Protein 1 (HBP1))
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别名
- HBP1
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背景
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HBP1 antibody detects HMG-box transcription factor 1, a transcriptional repressor that modulates cell cycle progression, differentiation, and Wnt signaling. Encoded by the HBP1 gene on chromosome 7q22.3, this protein belongs to the high mobility group (HMG) family of DNA-binding transcription factors. HBP1 acts as a nuclear regulator that represses proliferation-associated genes, integrating signals from growth factors, oncogenes, and stress pathways to maintain cellular homeostasis and differentiation potential.
Structurally, HBP1 is a 513-amino-acid nuclear protein of approximately 60 kilodaltons containing an HMG-box DNA-binding domain and transcriptional repression domains that interact with histone deacetylases (HDACs) and chromatin remodeling complexes. These interactions enable HBP1 to repress genes such as CCND1 (Cyclin D1) and N-MYC, thereby inhibiting uncontrolled cell proliferation. HBP1 also contains regulatory phosphorylation sites that control nuclear localization and DNA-binding affinity in response to extracellular cues.
The HBP1 antibody is widely used in cell cycle, cancer, and transcription research to study gene repression, differentiation, and tumor suppression mechanisms. Western blot analysis detects a 60 kilodalton band corresponding to HBP1, while immunofluorescence shows strong nuclear localization in epithelial and neuronal cells. This antibody enables detailed examination of transcriptional networks controlling growth arrest and lineage commitment.
Functionally, HBP1 suppresses oncogenic transformation by inhibiting Wnt/beta-catenin signaling and antagonizing MYC-dependent transcription. It also promotes senescence and apoptosis in response to DNA damage and oxidative stress, acting as a barrier to tumorigenesis. Reduced HBP1 expression or mutation is associated with breast, lung, and colon cancers, where loss of repression contributes to hyperproliferation. Beyond cancer, HBP1 regulates differentiation programs in neurons, adipocytes, and muscle cells by coordinating chromatin remodeling and transcriptional silencing. The HBP1 antibody provides a valuable tool for exploring these pathways and assessing transcriptional regulation in normal and diseased tissues. NSJ Bioreagents validates this antibody for its applications, ensuring specificity and consistency in transcriptional research applications. -
UniProt
- O60381
抗原
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