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beta Amyloid 抗体 (AA 500-700)

This 小鼠 单克隆 antibody specifically detects beta Amyloid in IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7875428
发货至: 中国
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Quick Overview for beta Amyloid 抗体 (AA 500-700) (ABIN7875428)

抗原

See all beta Amyloid (Abeta) 抗体
beta Amyloid (Abeta) (Amyloid beta (Abeta))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This beta Amyloid antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

APP-3667
  • 抗原表位

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    AA 500-700

    原理

    Amyloid beta Antibody / APP (azide and preservative free)

    纯化方法

    Protein A/G affinity

    免疫原

    A recombinant fragment (within amino acids 500-700) of human APP protein was used as the immunogen for the Amyloid beta antibody.

    亚型

    IgG2b, kappa
  • 应用备注

    Optimal dilution of the Amyloid beta antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    -20 °C

    储存方法

    Aliquot the Amyloid beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    beta Amyloid (Abeta) (Amyloid beta (Abeta))

    别名

    Amyloid beta

    背景

    Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the b-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid b/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.

    UniProt

    P05067

    途径

    Inflammasome
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