Recombinant beta Amyloid 抗体 (AA 500-700)
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Quick Overview for Recombinant beta Amyloid 抗体 (AA 500-700) (ABIN7875427)
抗原
See all beta Amyloid (Abeta) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 500-700
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原理
- Recombinant Amyloid beta Antibody / APP
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纯化方法
- Protein A affinity
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免疫原
- A portion of amino acids 500-700 from human APP protein was used as the immunogen for the recombinant Amyloid beta antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the recombinant Amyloid beta antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant Amyloid beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- beta Amyloid (Abeta) (Amyloid beta (Abeta))
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别名
- Amyloid beta
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背景
- Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the beta-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the 4 kDa Amyloid beta/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.
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UniProt
- P05067
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途径
- Inflammasome
抗原
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