CEACAM1 抗体 (AA 50-250)
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Quick Overview for CEACAM1 抗体 (AA 50-250) (ABIN7875336)
抗原
See all CEACAM1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 50-250
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原理
- Biliary glycoprotein 1 Antibody / BGP-1 / CEACAM1 (azide and preservative free)
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纯化方法
- Protein G affinity
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免疫原
- A portion of amino acids 50-250 from human CEACAM1 protein was used as the immunogen for the Biliary glycoprotein 1 antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the Biliary glycoprotein 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the Biliary glycoprotein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1))
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别名
- Biliary glycoprotein 1
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背景
- Carcinoembryonic antigen (CEA) is one of the most commonly used tumor markers in serum immunoassay determinations of carcinoma. Members of the CEACAM (carcinoembryonic antigen-related cell adhesion molecule) family contain a single N domain, with structural homology to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constantlike A and/or B domains. CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1), also known as BGP or BGP1, is a 526 amino acid protein that exists as seven alternatively spliced isoforms, some of which localize to the cell membranes, while others are secreted. One of several members of the CEACAM family, CEACAM1 contains one Ig-like V-type domain and three Ig-like C2-type domains and is thought to play a role in a variety of cellular activities, including angiogenesis, apoptosis, arrangement of tissue threedimensional structure and modulation of innate and adaptive immune responses. Additionally, CEACAM1 is underexpressed in colorectal cancers, suggesting a role in tumor suppression.
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UniProt
- P13688
抗原
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