MADD 抗体 (AA 5-329)
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Quick Overview for MADD 抗体 (AA 5-329) (ABIN7875304)
抗原
See all MADD 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 5-329
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原理
- MADD Antibody / MAP kinase-activating death domain
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human MADD recombinant protein (Position: K5-Y329) was used as the immunogen for the MADD antibody.
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亚型
- IgG
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anti-MAP-Kinase Activating Death Domain (MADD) antibody
KD Validated MADD 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB110 unconjugated Recombinant Antibody
anti-MAP-Kinase Activating Death Domain (MADD) antibodyMADD 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (C-Term) antibodyMADD 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (AA 1597-1647) antibodyMADD 适用: 人 IHC, IF (p) 宿主: 兔 Polyclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (Internal Region) antibodyMADD 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (Internal Region) antibodyMADD 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (AA 751-800) antibodyMADD 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (AA 1597-1647) antibodyMADD 适用: 人 WB, IF (p), IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (C-Term) antibodyMADD 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the MADD antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MADD antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MADD (MAP-Kinase Activating Death Domain (MADD))
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别名
- MADD
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背景
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MADD antibody detects MAP kinase-activating death domain protein, encoded by the MADD gene. MAP kinase-activating death domain protein is a multi-domain protein involved in apoptosis regulation, MAPK signaling, and vesicle trafficking. MADD antibody provides researchers with a specific reagent for studying TNF receptor signaling, neurodegeneration, and cancer.
MAP kinase-activating death domain protein interacts with TNF receptor 1 and other death receptors through its death domain, modulating apoptosis and survival. Research using MADD antibody has shown that it can function as an anti-apoptotic factor by inhibiting TNF-induced cell death, while simultaneously promoting MAP kinase signaling pathways that enhance proliferation. This dual role highlights MADD as a regulator of cell fate decisions.
Studies with MADD antibody have revealed that MADD is widely expressed but is particularly abundant in brain, endocrine tissues, and tumors. It is expressed as multiple isoforms through alternative splicing, including long and short forms that differ in their ability to regulate apoptosis and signaling. These isoforms allow MADD to act as a context-dependent modulator of signaling cascades.
Dysregulation of MAP kinase-activating death domain protein has been associated with cancer and neurodegenerative disease. Research using MADD antibody has shown that overexpression supports tumor growth by suppressing apoptosis, while mutations or altered expression in neurons contribute to neurodegenerative pathology. Elevated expression has also been observed in thyroid cancers and other tumors, positioning MADD as a potential biomarker and therapeutic target.
Beyond apoptosis, MADD participates in intracellular trafficking. Research using MADD antibody has demonstrated interactions with Rab3 and related GTPases, regulating synaptic vesicle release and exocytosis. This adds a neurobiological dimension to MADD function and explains its abundance in neurons.
MADD antibody is widely applied in western blotting, immunohistochemistry, and immunoprecipitation. Western blotting quantifies isoform expression across tissues, immunohistochemistry demonstrates tumor expression, and immunoprecipitation identifies receptor and GTPase interactions. These applications make MADD antibody indispensable for apoptosis, signaling, and cancer research.
By providing validated MADD antibody reagents, NSJ Bioreagents supports studies into TNF receptor pathways, apoptosis, and disease. Detection of MAP kinase-activating death domain protein provides researchers with insight into how death domain proteins regulate survival and pathology. -
UniProt
- Q8WXG6
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途径
- Caspase Cascade in Apoptosis
抗原
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