FOXM1 抗体 (AA 48-763)
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Quick Overview for FOXM1 抗体 (AA 48-763) (ABIN7875216)
抗原
See all FOXM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 48-763
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原理
- FOXM1 Antibody / Forkhead box protein M1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human FOXM1 recombinant protein (Position: K48-Q763) was used as the immunogen for the FOXM1 antibody.
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亚型
- IgG
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anti-Forkhead Box M1 (FOXM1) (AA 702-801) antibody
FOXM1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 5G10 unconjugated
anti-Forkhead Box M1 (FOXM1) (Middle Region) antibodyFOXM1 适用: 人, 大鼠, 小鼠, 犬, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) (AA 209-460) antibodyFOXM1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) (AA 649-748) antibodyFOXM1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 6F11A8 unconjugated
anti-Forkhead Box M1 (FOXM1) (C-Term) antibodyKO Validated FOXM1 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) antibodyKO Validated FOXM1 适用: 人 WB, IP, IHC (p), ChIP 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) (N-Term) antibodyFOXM1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) (AA 22-110) antibodyFOXM1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2H4 unconjugated
anti-Forkhead Box M1 (FOXM1) (AA 650-700) antibodyFOXM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Monoclonal BLR365N unconjugated Recombinant Antibody
anti-Forkhead Box M1 (FOXM1) (AA 301-400) antibodyFOXM1 适用: 人 ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the FOXM1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the FOXM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- FOXM1 (Forkhead Box M1 (FOXM1))
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别名
- FOXM1
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背景
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FOXM1 antibody detects Forkhead box protein M1, encoded by the FOXM1 gene on chromosome 12p13.33. FOXM1 antibody is widely used in studies of cell cycle regulation, transcription, and cancer biology. FOXM1 is a member of the forkhead box (FOX) family of transcription factors, characterized by a conserved winged-helix DNA-binding domain. It plays critical roles in G1/S and G2/M transitions of the cell cycle, controlling genes required for DNA replication, mitosis, and cytokinesis. Expression is high in proliferating cells and embryonic tissues, but normally downregulated in differentiated, non-dividing cells.
Structurally, FOXM1 contains an N-terminal repressor domain, a central forkhead DNA-binding domain, and a C-terminal transactivation domain. Its activity is regulated by phosphorylation, with cyclin-CDK complexes and MAPKs activating FOXM1 during the cell cycle. Alternative splicing produces isoforms with distinct transcriptional activities, including FOXM1a (inactive), FOXM1b, and FOXM1c (active in proliferation).
Functionally, FOXM1 drives expression of cell cycle regulators such as cyclin B1, cyclin D1, PLK1, and Aurora B kinase. It ensures proper chromosome segregation, spindle assembly, and DNA repair. Loss of FOXM1 impairs proliferation and causes mitotic defects, while overexpression accelerates tumorigenesis. Researchers use FOXM1 antibody to study transcriptional regulation, cell cycle control, and tumor progression.
Clinically, FOXM1 is strongly associated with cancer. Overexpression occurs in breast, liver, prostate, lung, and brain tumors, correlating with aggressive phenotypes and poor prognosis. FOXM1 promotes tumor growth by enhancing proliferation, metastasis, angiogenesis, and therapy resistance. Targeting FOXM1 is an emerging therapeutic strategy, with inhibitors under development. Beyond oncology, FOXM1 also participates in tissue repair, stem cell biology, and aging processes. NSJ Bioreagents provides FOXM1 antibody for use in oncology, stem cell, and regenerative medicine research.
Experimentally, FOXM1 antibody is applied in western blotting to detect the ~80i 1/290 kDa protein, in immunohistochemistry to assess tumor expression, and in immunofluorescence microscopy to study nuclear localization. ChIP assays using FOXM1 antibody help identify direct gene targets of this transcription factor. -
UniProt
- Q08050
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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