SNRK 抗体 (AA 48-750)
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Quick Overview for SNRK 抗体 (AA 48-750) (ABIN7875214)
抗原
See all SNRK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 48-750
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原理
- SNRK Antibody / SNF-related serine/threonine-protein kinase
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SNRK recombinant protein (Position: D48-E750) was used as the immunogen for the SNRK antibody.
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亚型
- IgG
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anti-SNF Related Kinase (SNRK) (AA 320-349) antibody
SNRK 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB09439 unconjugated
anti-SNF Related Kinase (SNRK) (AA 1-765) antibodySNRK 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SNF Related Kinase (SNRK) (AA 340-360) antibodySNRK 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SNF Related Kinase (SNRK) (AA 140-240) antibodySNRK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SNF Related Kinase (SNRK) (AA 539-588) antibodySNRK 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-SNF Related Kinase (SNRK) (AA 683-710), (C-Term) antibodySNRK 适用: 小鼠 WB 宿主: 兔 Polyclonal RB37138 unconjugated
anti-SNF Related Kinase (SNRK) (Middle Region) antibodySNRK 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, 犬 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SNRK antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SNRK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SNRK (SNF Related Kinase (SNRK))
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别名
- SNRK
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背景
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SNRK antibody detects SNF-related serine/threonine-protein kinase, a cytoplasmic and nuclear kinase encoded by the SNRK gene on chromosome 3q25.1. SNRK belongs to the AMP-activated protein kinase (AMPK)-related kinase family and functions as an energy sensor that regulates metabolism, inflammation, and cellular stress responses. The SNRK protein localizes to both cytoplasm and nucleus, where it phosphorylates substrates involved in energy metabolism, autophagy, and cardiac development. Like other AMPK family kinases, SNRK responds to changes in cellular ATP levels, linking nutrient availability to metabolic adaptation.
SNRK antibody identifies a kinase containing an N-terminal catalytic domain with the conserved activation loop threonine residue, followed by a unique C-terminal regulatory region that mediates protein-protein interactions. Activation of SNRK occurs via phosphorylation by upstream kinases such as LKB1. Once activated, SNRK phosphorylates downstream targets that regulate glucose uptake, fatty acid oxidation, and mitochondrial function. It plays a key role in maintaining cellular energy homeostasis under metabolic stress.
In cardiac tissue, SNRK supports myocardial energy efficiency and contractile function by modulating lipid metabolism and mitochondrial biogenesis. Loss of SNRK impairs mitochondrial respiration and increases susceptibility to metabolic disorders. In neurons, SNRK contributes to synaptic vesicle trafficking and axonal growth through phosphorylation of cytoskeletal and vesicle-associated proteins. Additionally, SNRK modulates inflammatory pathways by phosphorylating NF-kappaB regulators and promoting macrophage polarization toward an anti-inflammatory phenotype.
Pathway involvement of SNRK includes the AMPK signaling network, where it acts downstream of metabolic stress sensors to control autophagy, oxidative metabolism, and lipid catabolism. The kinase also participates in developmental signaling related to angiogenesis and cardiogenesis. Studies have shown that SNRK expression increases during fasting or hypoxia, supporting its role in adaptive metabolic regulation. Structurally, SNRK shares homology with other AMPK family kinases such as MARK2 and NUAK1, containing conserved ATP-binding and activation loop motifs.
Clinically, alterations in SNRK expression have been associated with obesity, insulin resistance, and heart disease. In the nervous system, SNRK dysregulation may contribute to neuroinflammation and neurodegeneration. Genome-wide association studies have linked SNRK variants to lipid metabolism disorders and coronary artery disease risk. The kinase's regulatory control of energy metabolism and inflammatory responses makes it a promising therapeutic target for metabolic and cardiovascular disease research.
Immunohistochemical staining using SNRK antibody shows cytoplasmic and nuclear localization in cardiac myocytes, neurons, and hepatocytes. The SNRK antibody from NSJ Bioreagents is a powerful tool for studying AMPK-related kinase signaling, mitochondrial regulation, and metabolic adaptation pathways. -
UniProt
- Q9NRH2
抗原
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