PAS1C1 抗体 (AA 48-349)
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Quick Overview for PAS1C1 抗体 (AA 48-349) (ABIN7875205)
抗原
See all PAS1C1 (IFLTD1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 48-349
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原理
- LMNTD1 Antibody / Lamin tail domain-containing protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human LMNTD1 recombinant protein (Position: Y48-E349) was used as the immunogen for the LMNTD1 antibody.
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亚型
- IgG
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anti-Intermediate Filament Tail Domain Containing 1 (IFLTD1) antibody
IFLTD1 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Intermediate Filament Tail Domain Containing 1 (IFLTD1) (AA 113-291) antibodyIFLTD1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Intermediate Filament Tail Domain Containing 1 (IFLTD1) (Middle Region) antibodyIFLTD1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the LMNTD1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the LMNTD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PAS1C1 (IFLTD1) (Intermediate Filament Tail Domain Containing 1 (IFLTD1))
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别名
- LMNTD1
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背景
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LMNTD1 antibody detects Lamin tail domain-containing protein 1, a poorly characterized nuclear envelope-associated protein believed to play roles in chromatin organization, nuclear structure, and cell differentiation. LMNTD1 is part of the broader family of lamin-associated proteins that contribute to the mechanical stability and spatial arrangement of the nucleus. The LMNTD1 antibody is used in studies of nuclear architecture, gene expression control, and tissue-specific nuclear envelope composition.
LMNTD1 is encoded by the LMNTD1 gene located on human chromosome 8p21.3. The protein is approximately 63 kilodaltons and characterized by a conserved lamin tail domain that mediates binding to lamins A/C and chromatin-associated factors. LMNTD1 localizes to the inner nuclear membrane, where it may anchor chromatin regions and participate in gene silencing through lamina-associated domains (LADs).
The LMNTD1 antibody detects a 63 kilodalton band in western blot analysis and shows nuclear rim staining under confocal microscopy. Although its function remains incompletely defined, LMNTD1 is proposed to stabilize nuclear structure during differentiation and respond to mechanical stress transmitted through the cytoskeleton. Expression studies indicate enrichment in testis, brain, and embryonic tissues, suggesting developmental and reproductive roles.
Emerging data suggest LMNTD1 interacts with components of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, potentially influencing nuclear positioning and signal transduction. Altered LMNTD1 expression has been observed in certain cancers and developmental disorders, where disrupted nuclear architecture correlates with genomic instability and transcriptional dysregulation.
By linking nuclear lamina integrity with chromatin organization, LMNTD1 contributes to structural and functional compartmentalization of the nucleus. NSJ Bioreagents provides a validated LMNTD1 antibody optimized for western blot, flow cytometry, and nuclear envelope studies, facilitating research into nuclear mechanics, gene silencing, and developmental regulation. -
UniProt
- Q8N9Z9
抗原
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