HBZ 抗体 (AA 48-142)
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Quick Overview for HBZ 抗体 (AA 48-142) (ABIN7875179)
抗原
See all HBZ 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 48-142
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原理
- HBZ Antibody / Hemoglobin zeta
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human HBZ recombinant protein (Position: D48-R142) was used as the immunogen for the HBZ antibody.
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亚型
- IgG
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anti-Hemoglobin, zeta (HBZ) (AA 1-81) antibody
HBZ 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1G10 unconjugated
anti-Hemoglobin, zeta (HBZ) (AA 1-142) antibodyHBZ 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C4-1D5 unconjugated
anti-Hemoglobin, zeta (HBZ) antibodyHBZ 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hemoglobin, zeta (HBZ) (N-Term) antibodyHBZ 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hemoglobin, zeta (HBZ) (AA 31-80) antibodyHBZ 适用: 人, 大鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hemoglobin, zeta (HBZ) (AA 1-142) antibodyHBZ 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hemoglobin, zeta (HBZ) (AA 95-123), (C-Term) antibodyHBZ 适用: 人 WB 宿主: 兔 Polyclonal RB41010 unconjugated
anti-Hemoglobin, zeta (HBZ) (N-Term) antibodyHBZ 适用: 人, 大鼠, 小鼠, 马, Cow, 山羊, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hemoglobin, zeta (HBZ) (AA 1-81) antibodyHBZ 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1G10 unconjugated
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应用备注
- Optimal dilution of the HBZ antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the HBZ antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- HBZ (Hemoglobin, zeta (HBZ))
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别名
- HBZ
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背景
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HBZ antibody detects Hemoglobin subunit zeta, encoded by the HBZ gene on chromosome 16p13.3. HBZ antibody is widely used in hematology, developmental biology, and globin gene regulation research. Hemoglobin zeta is an embryonic alpha-like globin expressed during early development in yolk sac-derived erythrocytes. It participates in embryonic hemoglobins (Hb Portland-1 and Hb Portland-2) that provide oxygen transport before fetal hemoglobins are expressed. Expression of HBZ is normally silenced after embryonic development as gamma and beta globins become dominant.
Structurally, Hemoglobin zeta is a ~16 kDa globin protein that forms heterotetramers with epsilon and gamma globins during early development. Its globin fold binds heme, enabling reversible oxygen binding. The protein sequence is highly homologous to alpha globin, reflecting its evolutionary relationship. Despite being developmentally restricted, HBZ can be re-expressed in certain pathologies.
Functionally, Hemoglobin zeta provides oxygen transport in the embryonic circulation and supports survival of primitive erythrocytes. Its transient expression is essential for early development. Researchers use HBZ antibody to investigate globin gene switching, embryonic hematopoiesis, and hemoglobinopathies.
Clinically, persistence of Hemoglobin zeta expression has been observed in some alpha-thalassemias and hematological malignancies. HBZ reactivation may contribute to altered oxygen transport or serve as a biomarker of erythroid stress. Genetic disorders affecting HBZ expression impact early embryonic viability. NSJ Bioreagents provides HBZ antibody for developmental hematology and globin research.
Experimentally, HBZ antibody is used in western blotting to detect the ~16 kDa protein, in immunohistochemistry to study embryonic tissue expression, and in ELISA to quantify hemoglobin zeta in blood samples. Molecular assays with HBZ antibody support studies of globin gene regulation. -
UniProt
- P02008
抗原
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