PRAME 抗体 (AA 476-502)
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北京 101111
Quick Overview for PRAME 抗体 (AA 476-502) (ABIN7875177)
抗原
See all PRAME 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 476-502
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原理
- MAPE Antibody / PRAME
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纯化方法
- Antigen affinity
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免疫原
- A portion of amino acids 476-502 from the human protein was used as the immunogen for the MAPE antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the MAPE antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the MAPE antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))
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别名
- MAPE
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背景
- MAPE (Melanoma antigen preferentially expressed in tumors), also called PRAME (Preferentially expressed antigen of melanoma), is a protein that is preferentially expressed in tumors, particularly in melanoma. It plays a vital role in regulating cell proliferation, migration, and invasion, making it a promising target for therapeutic interventions. Studies have shown that the overexpression of MAPE protein is associated with aggressive melanoma subtypes, indicating its potential as a prognostic biomarker in melanoma patients.
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UniProt
- P78395
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途径
- Retinoic Acid Receptor Signaling Pathway, Nuclear Hormone Receptor Binding
抗原
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