PARP15 抗体 (AA 47-555)
The 兔 多克隆 anti-PARP15 antibody (ABIN7875163) specifically detects PARP15 in WB, ELISA, FACS, ICC, IF 和 IHC.
The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN7875163
发货至:
中国
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Contact Info
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中国
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Quick Overview for PARP15 抗体 (AA 47-555) (ABIN7875163)
抗原
See all PARP15 抗体
PARP15
(Poly (ADP-Ribose) Polymerase Family, Member 15 (PARP15))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This PARP15 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC)
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抗原表位
- AA 47-555
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原理
- PARP15 Antibody / Poly ADP-ribose polymerase 15
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human PARP15 recombinant protein (Position: N47-R555) was used as the immunogen for the PARP15 antibody.
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亚型
- IgG
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anti-Poly (ADP-Ribose) Polymerase Family, Member 15 (PARP15) (AA 1-444) antibody
PARP15 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PARP15 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PARP15 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PARP15 (Poly (ADP-Ribose) Polymerase Family, Member 15 (PARP15))
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别名
- PARP15
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背景
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PARP15 antibody recognizes Poly (ADP-ribose) polymerase 15, an enzyme belonging to the PARP family involved in ADP-ribosylation, a post-translational modification regulating transcription, DNA repair, and stress responses. Unlike the classical DNA repair PARPs, PARP15 functions primarily in transcriptional repression and RNA processing. It possesses both mono-ADP-ribosyltransferase and macro domains, allowing it to modify specific target proteins. The PARP15 antibody is an essential reagent for studies of ADP-ribosylation signaling, chromatin dynamics, and cellular stress adaptation.
PARP15 is encoded by the PARP15 gene located on human chromosome 3q21.1. The protein comprises two N-terminal macro domains, a WWE domain involved in proteini 1/2protein interactions, and a C-terminal catalytic PARP domain. PARP15 localizes mainly to the nucleus and cytoplasmic granules, where it may regulate mRNA metabolism and response to stress. It has been implicated in cell survival pathways, as well as in the regulation of transcription factors under conditions of nutrient deprivation or oxidative stress.
Research using the PARP15 antibody has demonstrated its involvement in cancer cell proliferation and inflammation. Aberrant expression of PARP15 has been observed in lymphomas and certain solid tumors, where it may contribute to altered transcriptional control and resistance to apoptosis. Western blot analysis typically detects a band at approximately 74i 1/278 kDa. Immunocytochemical staining shows both nuclear and cytoplasmic localization, depending on cell type and stress conditions. Functional studies suggest that PARP15 can auto-modify and regulate its own enzymatic activity, similar to other PARP family members.
In recent years, PARP15 has attracted attention as part of the broader ADP-ribosylation signaling network, which includes enzymes, hydrolases, and binding proteins that control protein modification during stress responses. The antibody supports exploration of this enzyme's role in RNA granule formation, viral defense, and oncogenic signaling pathways. NSJ Bioreagents provides a validated PARP15 antibody for applications such as western blot, immunohistochemistry, and immunofluorescence, ensuring reliable results across molecular biology and cancer research contexts. -
UniProt
- Q460N3
抗原
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