Recombinant AMH 抗体 (AA 460-560)
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Quick Overview for Recombinant AMH 抗体 (AA 460-560) (ABIN7875130)
抗原
See all AMH 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 460-560
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原理
- Muellerian Inhibiting Factor Antibody / Anti-Muellerian Hormone
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纯化方法
- Protein A/G affinity
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免疫原
- A portion of amino acids 460-560 from the human protein was used as the immunogen for the Muellerian Inhibiting Factor antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Muellerian Inhibiting Factor antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Muellerian Inhibiting Factor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- AMH (Anti-Mullerian Hormone (AMH))
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别名
- Muellerian Inhibiting Factor
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背景
- The transforming growth factor superfamily proteins are involved in embryonic development and adult tissue homeostasis. The Muellerian inhibiting factor (MIF), also called Muellerian-inhibiting substance (MIS) and Anti-Muellerian hormone (AMH), glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIF and testosterone, the presence of which result in male offspring. Absence of MIF and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIF causes regression of the Muellerian duct. MIF inhibits the growth of tumors derived from tissues of Mullerian duct origin. It can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
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UniProt
- P03971
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途径
- Negative Regulation of Hormone Secretion
抗原
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