APOA1BP 抗体 (AA 46-288)
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北京 101111
Quick Overview for APOA1BP 抗体 (AA 46-288) (ABIN7875118)
抗原
See all APOA1BP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 46-288
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原理
- NAXE Antibody / NAD(P)HX epimerase
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human NAXE recombinant protein (Position: R46-Q288) was used as the immunogen for the NAXE antibody.
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亚型
- IgG
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anti-Apolipoprotein A-I Binding Protein (APOA1BP) (AA 118-282) antibody
APOA1BP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein A-I Binding Protein (APOA1BP) (Internal Region) antibodyAPOA1BP 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein A-I Binding Protein (APOA1BP) (AA 121-170) antibodyAPOA1BP 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein A-I Binding Protein (APOA1BP) (AA 1-185) antibodyAPOA1BP 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Apolipoprotein A-I Binding Protein (APOA1BP) (C-Term) antibodyVerified APOA1BP 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Apolipoprotein A-I Binding Protein (APOA1BP) (AA 48-170) antibodyAPOA1BP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein A-I Binding Protein (APOA1BP) (Internal Region) antibodyAPOA1BP 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein A-I Binding Protein (APOA1BP) (AA 54-282) antibodyAPOA1BP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein A-I Binding Protein (APOA1BP) (Center) antibodyAPOA1BP 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the NAXE antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the NAXE antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- APOA1BP (Apolipoprotein A-I Binding Protein (APOA1BP))
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别名
- NAXE
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背景
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The NAXE antibody targets NAD(P)HX epimerase, an enzyme encoded by the NAXE gene that catalyzes the interconversion of the R and S epimers of NADHX and NADPHX. These damaged forms of NADH and NADPH arise through hydration of nicotinamide cofactors under stress conditions. NAD(P)HX epimerase acts together with NAD(P)HX dehydratase to repair these inactive metabolites, maintaining cofactor homeostasis and protecting cells from metabolic imbalance. The NAXE antibody enables precise detection of this enzyme in studies of cofactor metabolism, mitochondrial function, and cellular stress response.
NAD(P)HX epimerase localizes to both the cytosol and mitochondria, reflecting its role in multiple redox compartments. It is essential for the NAD(P)HX repair system, which safeguards the integrity of cellular redox reactions by regenerating functional NADH and NADPH. The NAXE antibody allows researchers to analyze this protective mechanism, revealing how cells maintain coenzyme pools under conditions of heat, oxidative, or metabolic stress. Loss of NAXE function leads to accumulation of toxic NADHX derivatives, disrupting energy metabolism and enzymatic activity.
Mutations in the NAXE gene cause a rare neurometabolic disorder characterized by recurrent encephalopathy and neurodegeneration, particularly following febrile illness. The NAXE antibody supports mechanistic studies into this disease, helping identify tissue-specific expression and enzyme deficiency in patient-derived samples. Defective NAD(P)HX epimerase activity compromises mitochondrial respiration and redox balance, underscoring its essential role in cellular survival.
Beyond its role in repair metabolism, NAD(P)HX epimerase contributes to stress adaptation and antioxidant defense. It ensures a continuous supply of NAD(P)H required for reductive biosynthesis and detoxification pathways. The NAXE antibody supports quantitative analyses of enzyme regulation in models of oxidative stress, aging, and metabolic disorders. Dysregulation of NAD(P)HX repair enzymes has also been linked to impaired neuronal function and energy deficiency syndromes.
The NAXE antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, providing characteristic mitochondrial and cytosolic staining. NSJ Bioreagents provides this antibody with validated specificity and reproducibility for biochemistry, metabolism, and neuroscience research. By enabling accurate detection of NAD(P)HX epimerase, the NAXE antibody advances understanding of cofactor repair, mitochondrial redox regulation, and neuroprotective metabolic pathways. -
UniProt
- Q8NCW5
抗原
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