FOXM1 抗体 (AA 457-760)
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北京 101111
Quick Overview for FOXM1 抗体 (AA 457-760) (ABIN7875105)
抗原
See all FOXM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 457-760
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原理
- FOXM1 Antibody / Forkhead box protein M1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human FOXM1 recombinant protein (Position: Q457-P760) was used as the immunogen for the FOXM1 antibody.
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亚型
- IgG
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anti-Forkhead Box M1 (FOXM1) (AA 702-801) antibody
FOXM1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 5G10 unconjugated
anti-Forkhead Box M1 (FOXM1) (Middle Region) antibodyFOXM1 适用: 人, 大鼠, 小鼠, 犬, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) (AA 209-460) antibodyFOXM1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) (AA 649-748) antibodyFOXM1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 6F11A8 unconjugated
anti-Forkhead Box M1 (FOXM1) (C-Term) antibodyKO Validated FOXM1 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) antibodyKO Validated FOXM1 适用: 人 WB, IP, IHC (p), ChIP 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) (N-Term) antibodyFOXM1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) (AA 22-110) antibodyFOXM1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2H4 unconjugated
anti-Forkhead Box M1 (FOXM1) (AA 650-700) antibodyFOXM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Monoclonal BLR365N unconjugated Recombinant Antibody
anti-Forkhead Box M1 (FOXM1) (AA 301-400) antibodyFOXM1 适用: 人 ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the FOXM1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the FOXM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- FOXM1 (Forkhead Box M1 (FOXM1))
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别名
- FOXM1
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背景
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FOXM1 antibody detects Forkhead box protein M1, a transcription factor that regulates cell cycle progression, DNA replication, and mitotic gene expression. Encoded by the FOXM1 gene on chromosome 12p13.33, this nuclear protein belongs to the Forkhead family of transcription factors, characterized by a conserved winged-helix DNA-binding domain. FOXM1 functions as a key regulator of cell proliferation by activating genes required for G1/S and G2/M phase transitions, including cyclins, PLK1, and CDC25B.
FOXM1 localizes to the nucleus during interphase and associates with condensed chromosomes during mitosis. Its activity is controlled by phosphorylation through CDKs and PLK1, which modulate DNA-binding and transcriptional activation. FOXM1 also contributes to chromatin remodeling and genomic stability by facilitating DNA repair and replication stress responses. It serves as an essential factor in tissue regeneration, stem cell renewal, and oncogenic transformation.
The FOXM1 antibody is widely used in cancer, developmental, and cell cycle research to investigate proliferation control and transcriptional regulation. Western blot analysis detects a 90 kilodalton band corresponding to FOXM1, while immunofluorescence shows strong nuclear staining in proliferating cells. This antibody enables assessment of mitotic activity and transcriptional control mechanisms in both normal and cancerous tissues.
Overexpression of FOXM1 is a hallmark of many human cancers, where it promotes tumor growth, angiogenesis, and metastasis through activation of cell cycle and invasion-related genes. Its inhibition is being explored as a therapeutic strategy for targeting rapidly dividing cells. The FOXM1 antibody provides a reliable tool for studying transcriptional regulation of proliferation and tumorigenesis. NSJ Bioreagents validates this antibody for its applications, ensuring accurate and reproducible detection for transcriptional and oncogenic research. -
UniProt
- Q08050
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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