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BIN1 抗体 (AA 45-593)

This 兔 多克隆 antibody specifically detects BIN1 in WB, ELISA, IF 和 IHC (p). It exhibits reactivity toward 人, 小鼠 和 大鼠.
产品编号 ABIN7875077
发货至: 中国
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Quick Overview for BIN1 抗体 (AA 45-593) (ABIN7875077)

抗原

See all BIN1 抗体
BIN1 (Bridging Integrator 1 (BIN1))

适用

  • 78
  • 40
  • 22
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 61
  • 18
  • 1

克隆类型

  • 45
  • 35
多克隆

标记

  • 53
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
This BIN1 antibody is un-conjugated

应用范围

  • 66
  • 45
  • 34
  • 30
  • 23
  • 22
  • 19
  • 5
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 45-593

    原理

    BIN1 Antibody / Bridging integrator 1

    纯化方法

    Antigen affinity purified

    免疫原

    Recombinant human protein (amino acids E45-P593) was used as the immunogen for the BIN1 antibody.

    亚型

    IgG
  • 应用备注

    Optimal dilution of the BIN1 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    储存条件

    4 °C,-20 °C

    储存方法

    After reconstitution, the BIN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
  • 抗原

    BIN1 (Bridging Integrator 1 (BIN1))

    别名

    BIN1

    背景

    Myc box-dependent-interacting protein 1, also known as Bridging Integrator-1 and Amphiphysin-2 is a protein that in humans is encoded by the BIN1 gene. This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

    UniProt

    O00499
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