IFNGR1 抗体 (AA 45-347)
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北京 101111
Quick Overview for IFNGR1 抗体 (AA 45-347) (ABIN7875067)
抗原
See all IFNGR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 45-347
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原理
- Interferon gamma receptor 1 Antibody / Ifngr1
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纯化方法
- Antigen affinity purified
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免疫原
- An E.coli-derived mouse recombinant protein (amino acids L45-Q347) was used as the immunogen for the Interferon gamma receptor 1 antibody.
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亚型
- IgG
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anti-Interferon gamma Receptor 1 (IFNGR1) (AA 18-245) antibody
IFNGR1 适用: 人 WB, FACS, ELISA 宿主: 小鼠 Monoclonal 3E1A9 unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 270-489) antibodyIFNGR1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 18-245) antibodyIFNGR1 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 5H1C9 unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 1-489) antibodyIFNGR1 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) antibodyKD Validated IFNGR1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB13660 unconjugated Recombinant Antibody
anti-Interferon gamma Receptor 1 (IFNGR1) antibodyKO Validated IFNGR1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 431-480) antibodyIFNGR1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (C-Term) antibodyIFNGR1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 18-245) antibodyIFNGR1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 1-489) antibodyIFNGR1 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Interferon gamma receptor 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Interferon gamma receptor 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))
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别名
- Interferon gamma receptor 1
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背景
- Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the IFNGR1 gene. IFN-gamma plays key roles in both the innate and adaptive immune response. IFN-gamma activates the cytotoxic activity of innate immune cells, such as macrophages and NK cells. IFN-gamma production by NK cells and antigen presenting cells (APCs) promotes cell-mediated adaptive immunity by inducing IFN-gamma production by T lymphocytes, increasing class I and class II MHC expression, and enhancing peptide antigen presentation. Due to differences in the degree of glycosylation, there are 3 forms of IFN-gamma, with approximate molecular weights of 25, 20, and 15.5 kDa by SDS-PAGE. The anti-viral activity of IFN-gamma is due to its induction of PKR and other regulatory proteins. Binding of IFN-gamma to the IFNGR1/IFNGR2 complex promotes dimerization of the receptor complexes to form the (IFNGR1/IFNGR2)2 -IFN-gamma dimer. Binding induces a conformational change in receptor intracellular domains and signaling involves Jak1, Jak2, and Stat1. The critical role of IFN-gamma in amplification of immune surveillance and function is supported by increased susceptibility to pathogen infection by IFN-gamma or IFNGR knockout mice and in humans with inactivating mutations in IFNGR1 or IFNGR2. IFN-gamma also appears to have a role in atherosclerosis.
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UniProt
- P15261
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途径
- Interferon-gamma Pathway
抗原
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