RTL1 抗体 (AA 446-1327)
The 兔 多克隆 anti-RTL1 antibody (ABIN7875046) specifically detects RTL1 in WB, ELISA 和 FACS.
The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN7875046
发货至:
中国
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Quick Overview for RTL1 抗体 (AA 446-1327) (ABIN7875046)
抗原
See all RTL1 抗体
RTL1
(Retrotransposon-Like 1 (RTL1))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This RTL1 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Flow Cytometry (FACS)
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抗原表位
- AA 446-1327
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原理
- RTL1 Antibody / Retrotransposon like 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human RTL1 recombinant protein (Position: H446-R1327) was used as the immunogen for the RTL1 antibody.
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亚型
- IgG
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anti-Retrotransposon-Like 1 (RTL1) (AA 1330-1358), (C-Term) antibody
RTL1 适用: 人 WB 宿主: 兔 Polyclonal RB27543 unconjugated
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应用备注
- Optimal dilution of the RTL1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the RTL1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- RTL1 (Retrotransposon-Like 1 (RTL1))
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别名
- RTL1
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背景
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RTL1 antibody detects Retrotransposon-derived protein 1, encoded by the RTL1 gene on chromosome 14q32. RTL1 antibody is commonly used in research on placental biology, imprinting, and developmental regulation. RTL1, also known as PEG11 (paternally expressed gene 11), is an imprinted gene derived from a retrotransposon and plays essential roles in placental development, particularly in maintaining fetal capillary endothelial cells within the labyrinth layer of the placenta.
Structurally, RTL1 is a ~155 kDa protein with retroviral Gag and Pol-like domains, reflecting its origin from an ancient retrotransposon. Although lacking enzymatic retroviral activity, RTL1 retains structural features that support interactions with cellular machinery. Its expression is tightly regulated by imprinting, with only the paternal allele being active. RTL1 expression is restricted to placenta and certain fetal tissues, consistent with its developmental functions.
Functionally, RTL1 supports placental vascular development and fetal-maternal exchange. Knockout studies in mice reveal mid-gestation lethality due to defective placental capillaries. Overexpression, conversely, disrupts placental balance and fetal growth. RTL1 expression is regulated by antisense microRNAs encoded in the imprinted cluster, ensuring precise dosage. Researchers use RTL1 antibody to investigate placental biology, imprinting disorders, and retroelement-derived gene functions.
Clinically, altered RTL1 expression is associated with human imprinting disorders such as Kagami-Ogata syndrome and Temple syndrome, which involve abnormal dosage from the 14q32 region. Dysregulation of RTL1 may contribute to abnormal fetal growth and placental insufficiency. Its retrotransposon-derived nature highlights how ancient viral elements have been co-opted into mammalian development. NSJ Bioreagents provides RTL1 antibody for use in developmental biology and imprinting research.
Experimentally, RTL1 antibody is used in western blotting to detect the ~155 kDa protein, in immunohistochemistry to examine placental tissue, and in RNA-protein studies to assess regulatory interactions. It is a valuable tool for investigating imprinted gene expression and placental function. -
UniProt
- A6NKG5
抗原
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