GALNT2 抗体 (AA 442-571)
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Quick Overview for GALNT2 抗体 (AA 442-571) (ABIN7875029)
抗原
See all GALNT2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 442-571
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原理
- GALNT2 Antibody / Polypeptide N-acetylgalactosaminyltransferase 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GALNT2 recombinant protein (Position: H442-Q571) was used as the immunogen for the GALNT2 antibody.
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亚型
- IgG
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anti-UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-T2) (GALNT2) antibody
GALNT2 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-T2) (GALNT2) (AA 442-571) antibodyGALNT2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-T2) (GALNT2) (AA 26-53), (N-Term) antibodyGALNT2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23942 unconjugated
anti-UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-T2) (GALNT2) (AA 442-571) antibodyGALNT2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-T2) (GALNT2) (AA 272-523) antibodyGALNT2 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-T2) (GALNT2) (AA 32-62), (N-Term) antibodyGALNT2 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-T2) (GALNT2) (AA 473-571) antibodyGALNT2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GALNT2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GALNT2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GALNT2 (UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-T2) (GALNT2))
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别名
- GALNT2
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背景
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GALNT2 antibody detects Polypeptide N-acetylgalactosaminyltransferase 2, an enzyme that initiates mucin-type O-linked glycosylation by transferring N-acetylgalactosamine (GalNAc) to serine and threonine residues of target proteins. The UniProt recommended name is Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2). This enzyme is localized in the Golgi apparatus and is part of a family of glycosyltransferases that regulate protein processing, secretion, and cell signaling.
Functionally, GALNT2 antibody identifies a 571-amino-acid type II transmembrane protein with an N-terminal cytoplasmic tail, a single transmembrane helix, and a luminal catalytic domain. GALNT2 controls the first step of O-glycan biosynthesis, generating the Tn antigen precursor used for complex glycan assembly. Its substrate selectivity contributes to tissue-specific glycosylation patterns that affect protein stability, receptor signaling, and extracellular matrix composition. Through this activity, GALNT2 regulates cellular adhesion, immune recognition, and lipid metabolism.
The GALNT2 gene is located on chromosome 1q42.13 and is broadly expressed in liver, pancreas, intestine, and epithelial tissues. Genetic studies link GALNT2 variants to plasma lipid levels and susceptibility to metabolic disorders. Reduced GALNT2 expression impairs O-glycosylation of apolipoprotein C-III (ApoC3) and ANGPTL3, leading to altered triglyceride metabolism. Conversely, overexpression influences cell surface receptor function and proteolytic shedding of glycoproteins involved in inflammation and cancer progression.
In cellular signaling, GALNT2 participates in the regulation of the epidermal growth factor receptor (EGFR) and insulin receptor pathways. Aberrant O-glycosylation mediated by GALNT2 modifies receptor trafficking and ligand responsiveness. In cancer, dysregulated GALNT2 expression is associated with increased proliferation, migration, and metastasis in hepatocellular carcinoma and breast cancer. Conversely, its reduced expression can impair glycan-mediated cell communication and immune regulation.
GALNT2 antibody is used for immunohistochemistry, western blotting, and glycoproteomics studies to assess Golgi function, protein maturation, and post-translational modification patterns. The enzyme's activity is crucial for mucin biosynthesis, glycoprotein secretion, and metabolic balance. In metabolic research, GALNT2 serves as a biomarker linking glycosylation to lipid homeostasis and cardiovascular disease risk.
Structurally, GALNT2 contains a catalytic Gal/GalNAc-T motif and a C-terminal ricin-like lectin domain that determines substrate specificity. These features allow recognition of unmodified peptide regions and extension of O-linked glycans in a sequential manner. NSJ Bioreagents provides GALNT2 antibody reagents validated for use in glycosylation, metabolism, and oncology research to examine protein modification and trafficking mechanisms. -
UniProt
- Q10471
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途径
- Production of Molecular Mediator of Immune Response
抗原
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