GRM2 抗体 (AA 439-710)
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Quick Overview for GRM2 抗体 (AA 439-710) (ABIN7875001)
抗原
See all GRM2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 439-710
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原理
- GRM2 Antibody / Metabotropic Glutamate Receptor 2
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纯化方法
- Affinity purified
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免疫原
- A human recombinant protein (amino acids N439-A710) was used as the immunogen for the GRM2 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the GRM2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GRM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))
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别名
- GRM2
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背景
- Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. It is mapped to 3p21.2. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
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UniProt
- Q14416
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途径
- cAMP Metabolic Process, Dicarboxylic Acid Transport
抗原
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