CD235b/GYPB 抗体 (AA 43-91)
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北京 101111
Quick Overview for CD235b/GYPB 抗体 (AA 43-91) (ABIN7874978)
抗原
See all CD235b/GYPB (GYPB) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 43-91
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原理
- GYPB Antibody / Glycophorin B
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GYPB recombinant protein (Position: Q43-A91) was used as the immunogen for the GYPB antibody.
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亚型
- IgG
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anti-Glycophorin B (GYPB) (AA 21-91) antibody
GYPB 适用: 人 IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Glycophorin B (GYPB) (AA 22-51) antibodyGYPB 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB33617 unconjugated
anti-Glycophorin B (GYPB) (AA 1-91) antibodyGYPB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GYPB antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GYPB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- CD235b/GYPB (GYPB) (Glycophorin B (GYPB))
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别名
- GYPB
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背景
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GYPB antibody detects Glycophorin B, encoded by the GYPB gene. Glycophorin B is a major sialoglycoprotein of the erythrocyte membrane that contributes to blood group antigen expression, membrane structure, and host-pathogen interactions. GYPB antibody provides researchers with a specific reagent to study red blood cell biology, blood group systems, and disease processes involving erythrocyte surface proteins.
Glycophorin B is a single-pass transmembrane protein heavily glycosylated on its extracellular domain. Research using GYPB antibody has shown that it carries antigens of the MNS blood group system, including the S and s antigens. Variation in GYPB alleles results in polymorphism that defines clinically significant blood group phenotypes. These polymorphisms are essential for transfusion medicine and compatibility testing.
Studies with GYPB antibody have revealed that Glycophorin B contributes to erythrocyte membrane stability. By interacting with the cytoskeleton and forming complexes with other membrane proteins, it maintains cell shape and flexibility. Glycophorin B also provides a negatively charged surface that reduces red blood cell aggregation and contributes to circulation efficiency.
In infectious disease research, Glycophorin B is notable as a receptor for Plasmodium falciparum, the parasite responsible for malaria. Research using GYPB antibody has shown that parasite invasion efficiency depends on interactions with glycophorins, including Glycophorin B. Genetic variants of GYPB influence malaria susceptibility, making this protein highly relevant for host-pathogen interaction studies.
Dysregulation or mutation of GYPB can result in rare blood group phenotypes, which may cause challenges in transfusion compatibility. Studies with GYPB antibody have also suggested potential roles in erythroid development and signaling, although these functions remain less well defined compared to its structural and antigenic roles.
GYPB antibody is widely applied in flow cytometry, immunohistochemistry, and immunoblotting. Flow cytometry distinguishes blood group antigen expression on red cells, immunohistochemistry identifies surface expression patterns, and immunoblotting quantifies protein levels. These applications make GYPB antibody indispensable in transfusion medicine and infectious disease research.
By supplying validated GYPB antibody reagents, NSJ Bioreagents supports studies into erythrocyte biology, blood group systems, and host-pathogen interactions. Detection of Glycophorin B provides researchers with insight into how red cell surface proteins contribute to health and disease. -
UniProt
- P06028
抗原
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