STK32C 抗体 (AA 42-475)
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Quick Overview for STK32C 抗体 (AA 42-475) (ABIN7874926)
抗原
See all STK32C 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 42-475
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原理
- STK32C Antibody / Serine/threonine-protein kinase 32C
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human STK32C recombinant protein (Position: Q42-M475) was used as the immunogen for the STK32C antibody.
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亚型
- IgG
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anti-serine/threonine Kinase 32C (STK32C) (AA 1-369) antibody
STK32C 适用: 人 ELISA, WB, IHC (p) 宿主: 小鼠 Monoclonal 3B4 unconjugated
anti-serine/threonine Kinase 32C (STK32C) (Internal Region) antibodySTK32C 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 32C (STK32C) (AA 1-369) antibodySTK32C 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 4D12 unconjugated
anti-serine/threonine Kinase 32C (STK32C) antibodySTK32C 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the STK32C antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the STK32C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- STK32C (serine/threonine Kinase 32C (STK32C))
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别名
- STK32C
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背景
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STK32C antibody detects Serine/threonine-protein kinase 32C, a member of the STK32 family of kinases that includes STK32A and STK32B. STK32C is a cytoplasmic serine/threonine kinase involved in signal transduction pathways regulating cellular growth, metabolism, and stress responses. Although less characterized than its paralogs, STK32C has emerging importance in neuronal signaling and mitochondrial regulation. The STK32C antibody is used in research investigating kinase signaling networks, neurodevelopment, and protein phosphorylation control.
STK32C is encoded by the STK32C gene located on human chromosome 5q35.1. The protein is approximately 56 kilodaltons and contains a conserved serine/threonine kinase catalytic domain with typical subdomains I-XI, including an ATP-binding site and an activation loop. Expression profiling shows broad distribution across tissues, with enriched levels in brain, heart, and skeletal muscle, suggesting roles in excitable tissue function and mitochondrial homeostasis.
STK32C phosphorylates substrates involved in metabolic regulation and cytoskeletal dynamics, though its full substrate repertoire remains under study. In neuronal systems, STK32C expression increases during differentiation, implying a developmental regulatory function. Comparative analysis with STK32A and STK32B reveals overlapping but distinct substrate preferences and signaling responses, highlighting potential functional diversification among this kinase subfamily.
Recent phosphoproteomic analyses indicate that STK32C may participate in stress-activated signaling and mitochondrial fission control. Inhibition or silencing of STK32C disrupts mitochondrial morphology and reduces oxidative phosphorylation efficiency. This kinase may integrate metabolic status with energy homeostasis by phosphorylating mitochondrial or cytosolic target proteins. Additionally, preliminary data suggest a role in autophagic flux modulation and endoplasmic reticulum-mitochondria communication.
In cancer biology, STK32C has been implicated in cellular proliferation and invasion through phosphorylation of cytoskeletal effectors. Elevated expression correlates with poor prognosis in certain neuroblastoma and glioblastoma datasets, suggesting possible oncogenic behavior in nervous system tumors. In contrast, other studies report STK32C downregulation in degenerative neural conditions, implying context-dependent effects. The enzyme's unique sequence features, including an elongated C-terminal tail and regulatory motifs, suggest fine-tuned signaling modulation. NSJ Bioreagents provides a validated STK32C antibody optimized for its applications, enabling detailed investigation of serine/threonine kinase signaling and cellular metabolic adaptation. -
UniProt
- Q86UX6
抗原
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