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NARF 抗体 (AA 41-353)

The 兔 多克隆 anti-NARF antibody is suitable to detect NARF in samples from 人, 小鼠 和 大鼠. It has been validated for WB, ELISA 和 FACS.
产品编号 ABIN7874835
发货至: 中国
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Quick Overview for NARF 抗体 (AA 41-353) (ABIN7874835)

抗原

See all NARF 抗体
NARF (Nuclear Prelamin A Recognition Factor (NARF))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This NARF antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Flow Cytometry (FACS)
  • 抗原表位

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    AA 41-353

    原理

    NARF Antibody / Nuclear prelamin A recognition factor

    纯化方法

    Antigen affinity purified

    免疫原

    E. coli-derived recombinant human protein (amino acids H41-Q353) was used as the immunogen for the NARF antibody.

    亚型

    IgG
  • 应用备注

    Optimal dilution of the NARF antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    储存条件

    4 °C,-20 °C

    储存方法

    After reconstitution, the NARF antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
  • 抗原

    NARF (Nuclear Prelamin A Recognition Factor (NARF))

    别名

    NARF

    背景

    Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.

    UniProt

    Q9UHQ1
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