NARF 抗体 (AA 41-353)
Our Local Distributor
北京 101111
Quick Overview for NARF 抗体 (AA 41-353) (ABIN7874835)
抗原
See all NARF 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 41-353
-
原理
- NARF Antibody / Nuclear prelamin A recognition factor
-
纯化方法
- Antigen affinity purified
-
免疫原
- E. coli-derived recombinant human protein (amino acids H41-Q353) was used as the immunogen for the NARF antibody.
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal dilution of the NARF antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the NARF antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- NARF (Nuclear Prelamin A Recognition Factor (NARF))
-
别名
- NARF
-
背景
- Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.
-
UniProt
- Q9UHQ1
抗原
-