MYBBP1A 抗体 (AA 41-1058)
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北京 101111
Quick Overview for MYBBP1A 抗体 (AA 41-1058) (ABIN7874821)
抗原
See all MYBBP1A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 41-1058
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原理
- MYBBP1A Antibody / Myb-binding protein 1A
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human MYBBP1A recombinant protein (Position: D41-Q1058) was used as the immunogen for the MYBBP1A antibody.
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亚型
- IgG
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anti-Myb-Binding Protein 1A (MYBBP1A) (AA 1104-1328) antibody
MYBBP1A 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) (AA 1-1328) antibodyMYBBP1A 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) (C-Term) antibodyMYBBP1A 适用: 小鼠, 大鼠, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) (AA 1-1328) antibodyMYBBP1A 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) (AA 1201-1250) antibodyMYBBP1A 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) antibodyMYBBP1A 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) (AA 258-287), (N-Term) antibodyMYBBP1A 适用: 人 WB 宿主: 兔 Polyclonal RB23244 unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) (AA 450-500) antibodyMYBBP1A 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-Myb-Binding Protein 1A (MYBBP1A) antibodyMYBBP1A 适用: 人 IHC, ELISA, IF 宿主: 兔 Monoclonal 3A1 unconjugated Recombinant Antibody
anti-Myb-Binding Protein 1A (MYBBP1A) antibodyKD Validated MYBBP1A 适用: 人 WB 宿主: 小鼠 Monoclonal 25GB3890 unconjugated
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应用备注
- Optimal dilution of the MYBBP1A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MYBBP1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MYBBP1A (Myb-Binding Protein 1A (MYBBP1A))
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别名
- MYBBP1A
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背景
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MYBBP1A antibody detects Myb-binding protein 1A, encoded by the MYBBP1A gene. Myb-binding protein 1A is a nucleolar protein that participates in transcriptional regulation, ribosome biogenesis, and stress signaling. MYBBP1A antibody provides researchers with a versatile reagent for studying nuclear protein interactions, tumor suppression, and stress-responsive transcriptional programs.
Myb-binding protein 1A was first identified as a factor that interacts with the transcription factor c-Myb. Research using MYBBP1A antibody has shown that it acts as a transcriptional regulator by modulating Myb-dependent genes and other transcriptional pathways. It functions as a co-repressor or co-activator depending on cellular context, influencing cell proliferation and differentiation.
Studies with MYBBP1A antibody have revealed that the protein localizes to the nucleolus under basal conditions but translocates to the nucleoplasm upon cellular stress. This dynamic distribution links ribosome biogenesis to stress-responsive transcriptional regulation. MYBBP1A influences ribosomal RNA transcription, p53 activation, and chromatin remodeling, emphasizing its multifunctional nature.
Dysregulation of Myb-binding protein 1A has been linked to cancer and stress-related pathology. Research using MYBBP1A antibody has shown that reduced expression contributes to tumorigenesis by impairing p53-mediated responses. Conversely, overexpression can suppress tumor growth by activating apoptosis pathways. This dual role highlights its complex involvement in cancer biology.
Beyond cancer, MYBBP1A participates in metabolic regulation and cellular senescence. Research using MYBBP1A antibody has suggested roles in controlling NF-kB signaling, mitochondrial stress responses, and transcription of metabolic genes. These findings underscore its integration of stress responses with transcriptional networks.
MYBBP1A antibody is widely applied in western blotting, immunohistochemistry, and chromatin immunoprecipitation. Western blotting quantifies protein levels, immunohistochemistry demonstrates nucleolar localization, and chromatin immunoprecipitation identifies transcriptional binding partners. These applications make MYBBP1A antibody indispensable in nuclear biology and cancer research.
By providing validated MYBBP1A antibody reagents, NSJ Bioreagents supports studies into transcriptional regulation, stress signaling, and tumor suppression. Detection of Myb-binding protein 1A provides researchers with insight into how nucleolar proteins integrate ribosome biogenesis and stress responses. -
UniProt
- Q9BQG0
抗原
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