MX1 抗体 (AA 400-592)
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Quick Overview for MX1 抗体 (AA 400-592) (ABIN7874736)
抗原
See all MX1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 400-592
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原理
- Myxovirus resistance protein 1 Antibody / MX1 / MxA
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein sequence (within amino acids 400-592) from the human protein was used as the immunogen for the Myxovirus resistance protein 1 antibody.
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亚型
- IgG2, kappa
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应用备注
- Optimal dilution of the Myxovirus resistance protein 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Myxovirus resistance protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- MX1 (Myxovirus Resistance Protein 1 (MX1))
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别名
- Myxovirus resistance protein 1
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背景
- The Dynamin family of microtubule-associated proteins function as GTPases that are involved in microtubule bundling and endocytosis. In mice, Mx2 (myxovirus resistance protein 2) and Mx1 (myxovirus resistance protein 1) are members of the Dynamin family that are involved in the immune response to viral infections. Localized to the cytoplasm, Mx2 contains one GED domain and is expressed in response to viral infection or treatment by IFN-a/IFN-b. Once expression is induced, Mx2 accumulates in the cytoplasm and inhibits the replication of vesicular stomatitis virus (VSV), thereby conferring resistance to VSV infection. Unlike Mx2, Mx1 is localized to the nucleus where, upon induction by IFN-a/IFN-b, it provides selective resistance to infection by the highly lethal H5N1 influenza virus. In humans, MxA and MxB function in a similar manner to Mx1 and Mx2, conferring resistance to specific target viruses. Mx3 is a rat-specific member of the myxovirus resistance protein family.
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UniProt
- P20591
抗原
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