C9ORF72 抗体 (AA 40-77)
Our Local Distributor
北京 101111
Quick Overview for C9ORF72 抗体 (AA 40-77) (ABIN7874711)
抗原
See all C9ORF72 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 40-77
-
原理
- Zebrafish C9orf72 Antibody
-
纯化方法
- Antigen affinity chromatography
-
免疫原
- An E.coli-derived zebrafish C9orf72 recombinant protein (amino acids R40-E77) was used as the immunogen for the Zebrafish C9orf72 antibody.
-
亚型
- Ig Fraction
-
-
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 1-230) antibody
C9ORF72 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 391-481) antibodyC9ORF72 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 138-430) antibodyC9ORF72 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 396-424), (C-Term) antibodyC9ORF72 适用: 人 WB 宿主: 兔 Polyclonal RB27382 unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 1-481) antibodyC9ORF72 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 396-424) antibodyC9ORF72 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the Zebrafish C9orf72 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the Zebrafish C9orf72 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))
-
别名
- C9orf72
-
背景
- C9orf72 (chromosome 9 open reading frame 72) is a protein which in humans is encoded by the gene C9orf72. It is mapped to 9p21.2. The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.
-
UniProt
- Q6TLH8
抗原
-
