DBH 抗体 (AA 40-545)
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Quick Overview for DBH 抗体 (AA 40-545) (ABIN7874705)
抗原
See all DBH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 40-545
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原理
- DBH Antibody / Dopamine beta Hydroxylase
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纯化方法
- Affinity purified
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免疫原
- A human recombinant protein (amino acids S40-N545) was used as the immunogen for the DBH antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the DBH antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the DBH antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))
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别名
- DBH
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背景
- Dopamine beta-hydroxylase (DBH), also known as dopamine beta-monooxygenase, is an enzyme (EC1.14.17.1) that in humans is encoded by the DBH gene. Dopamine beta-hydroxylase catalyzes the chemical reaction. It is mapped to 9q34.2. The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.
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UniProt
- P09172
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途径
- Carbohydrate Homeostasis
抗原
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