NSUN6 抗体 (AA 40-400)
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北京 101111
Quick Overview for NSUN6 抗体 (AA 40-400) (ABIN7874698)
抗原
See all NSUN6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 40-400
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原理
- NSUN6 Antibody / NOP2/Sun RNA methyltransferase family member 6
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human NSUN6 recombinant protein (Position: E40-E400) was used as the immunogen for the NSUN6 antibody.
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亚型
- IgG
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anti-NOP2/Sun Domain Family, Member 6 (NSUN6) (AA 51-150) antibody
NSUN6 适用: 人 WB, IF (cc), IF (p), ELISA, ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NOP2/Sun Domain Family, Member 6 (NSUN6) (Center) antibodyNSUN6 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-NOP2/Sun Domain Family, Member 6 (NSUN6) (N-Term) antibodyNSUN6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-NOP2/Sun Domain Family, Member 6 (NSUN6) (N-Term) antibodyNSUN6 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-NOP2/Sun Domain Family, Member 6 (NSUN6) (N-Term) antibodyNSUN6 适用: 人, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-NOP2/Sun Domain Family, Member 6 (NSUN6) (N-Term) antibodyNSUN6 适用: 人, 小鼠, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the NSUN6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the NSUN6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NSUN6 (NOP2/Sun Domain Family, Member 6 (NSUN6))
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别名
- NSUN6
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背景
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NSUN6 antibody detects NOP2/Sun RNA methyltransferase family member 6, encoded by the NSUN6 gene on chromosome 10q22.1. NSUN6 antibody is widely used in RNA biology, epigenetics, and cancer research. NSUN6 belongs to the RNA cytosine methyltransferase family, catalyzing site-specific methylation of cytosine residues in tRNAs and possibly other RNAs. This modification, known as 5-methylcytosine, influences RNA stability, structure, and function.
Structurally, NSUN6 is a ~55 kDa cytoplasmic protein containing an RNA recognition motif and a conserved catalytic domain typical of cytosine-5 methyltransferases. It selectively modifies tRNAs at position C72 in the acceptor stem, a modification critical for efficient aminoacylation and translation. NSUN6 localizes predominantly in the cytoplasm but may also act in the nucleus under certain conditions.
Functionally, NSUN6 promotes translation fidelity and efficiency by stabilizing tRNA structure. It contributes to cellular stress responses, growth, and differentiation. Altered NSUN6 activity disrupts RNA modifications, impacting protein synthesis and cellular homeostasis. Researchers use NSUN6 antibody to study RNA epigenetics, translation control, and stress biology.
Clinically, dysregulation of RNA methyltransferases including NSUN6 is implicated in cancer, neurodevelopmental disorders, and viral infections. NSUN6 overexpression has been linked to certain tumors, suggesting a role in tumor growth. Conversely, loss-of-function may impair translation and stress adaptation. Because RNA modifications are emerging therapeutic targets, NSUN6 is an attractive focus for research. NSJ Bioreagents supplies NSUN6 antibody for epigenetics, cancer, and RNA biology studies.
Experimentally, NSUN6 antibody is applied in western blotting to detect the ~55 kDa protein, in immunofluorescence microscopy to visualize cytoplasmic distribution, and in RNA immunoprecipitation to map RNA substrates. Co-immunoprecipitation with NSUN6 antibody identifies protein partners in RNA methylation complexes. -
UniProt
- Q8TEA1
抗原
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